ArticleAmerican journal of epidemiology2018
Measurement of Vitamin D for Epidemiologic and Clinical Research: Shining Light on a Complex Decision.
Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- A systematic review and meta-analysis of circulating 25-hydroxyvitamin D concentration and vitamin D status worldwide.Journal of public health (Oxford, England) · 2025Pooled it
- Association of the vitamin D metabolism gene GC and CYP27B1 polymorphisms with cancer susceptibility: a meta-analysis and trial sequential analysis.Bioscience reports · 2019Pooled it
- Principal results of the VITamin D and OmegA-3 TriaL (VITAL) and updated meta-analyses of relevant vitamin D trials.The Journal of steroid biochemistry and molecular biology · 2020Trial
- Vitamin D, Marine n-3 Fatty Acids, and Primary Prevention of Cardiovascular Disease Current Evidence.Circulation research · 2020Trial
- Serum 25-hydroxyvitamin D in the VITamin D and OmegA-3 TriaL (VITAL): Clinical and demographic characteristics associated with baseline and change with randomized vitamin D treatment.Contemporary clinical trials · 2019Trial
- Association of Serum 25-Hydroxyvitamin D Levels With Acute Coronary Syndrome: A Case-Control Study.Cureus · 2026Article
- Circulating 25-Hydroxy-Vitamin D Levels in Menopausal and Postmenopausal Women in Italy: A Comparison of Four Analytical Methods.Diseases (Basel, Switzerland) · 2026Article
- Leveraging Menstrual Effluent to Investigate Vitamin D and Human Decidualization: A Potential Link with Fertility.The Journal of clinical endocrinology and metabolism · 2026Article
- Increased Levels of the Vitamin D Metabolite Ratio Are Protective Against Progression From Islet Autoimmunity to T1D.The Journal of clinical endocrinology and metabolism · 2026Article
- The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications.Journal of cell communication and signaling · 2026Review
- Associations of endocrine disrupting chemical biomarkers and their mixture with vitamin D biomarker concentrations in childhood: The HOME Study.Environmental research · 2026Article
- Vitamin D: recent advances, associated factors, and its role in combating non-communicable diseases.NPJ science of food · 2025Review
- Serum and urine metabolite correlates of vitamin D supplementation in the Atherosclerosis Risk in Communities (ARIC) study.Clinical nutrition ESPEN · 2025Article
- The ABCDs of Nutritional Assessment in Infectious Diseases Research.The Journal of infectious diseases · 2025Review
- Vitamin D Deficiency: Insights and Perspectives from a Five-Year Retrospective Analysis of Children from Northeastern Romania.Nutrients · 2024Article
- Review
- An HPLC-UV Method to Assess Human Plasma 25(OH)DNutrients · 2024Article
- Navigating Complexities: Vitamin D, Skin Pigmentation, and Race.The Journal of clinical endocrinology and metabolism · 2024Article
- Vitamin D and Depression: Racial Differences Suggest an Alternate Biomarker.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Association of cartilage metabolism biomarkers and 25(OH)D levels with muscle biomechanical functions in professional rowers and canoeists.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Vitamin D is a fat-soluble vitamin that is synthesized in the skin with exposure to sunlight or is ingested from dietary supplements or food. There has been a dramatic increase in research on vitamin D, linking it with health outcomes as varied as reproductive function, infection, cardiovascular disease, and cancer. The study of vitamin D has generated much excitement, partly because there is an ideal intervention: Low levels may be common and can be remedied with widely available supplements. Determination of vitamin D status is complex and has advanced dramatically in the past 5 years. In this paper, we begin by describing important considerations for measurement of total 25-hydroxyvitamin D (25(OH)D), the biomarker traditionally assessed in epidemiologic studies. While 25(OH)D remains the most commonly measured biomarker, emerging evidence suggests that other related analytes may contribute to the characterization of an individual's vitamin D status (e.g., vitamin D-binding protein, bioavailable and free 25(OH)D, the C-3 epimer of 25(OH)D, 1,25-dihydroxyvitamin D, and 24,25-dihydroxyvitamin D). The measurement of these analytes is also complex, and there are important considerations for deciding whether their measurement is warranted in new research studies. Herein we discuss these issues and provide the reader with an up-to-date synthesis of research on vitamin D measurement options and considerations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.