ArticlePloS one2017
Anti-inflammatory and wound healing activities of calophyllolide isolated from Calophyllum inophyllum Linn.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 111 citations in OpenAlex.
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- An Integrated Computational and Experimental Approach to Formulate Tamanu Oil Bigels as Anti-Scarring Agent.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Assessing the Anti-Aging and Wound Healing Capabilities ofMolecules (Basel, Switzerland) · 2023Article
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- In Silico Study of Novel Cyclodextrin Inclusion Complexes of Polycaprolactone and Its Correlation with Skin Regeneration.International journal of molecular sciences · 2023Article
- Microcurrent and Gold Nanoparticles Combined with Hyaluronic Acid Accelerates Wound Healing.Antioxidants (Basel, Switzerland) · 2022Article
- Optimisation of Calophyllum inophyllum seed oil nanoemulsion as a potential wound healing agent.BMC complementary medicine and therapies · 2022Article
- Wound healing effect of Carum carvi L. on the incised skin wound in male rats: Histopathology, total protein and biomechanical evaluations.Veterinary medicine and science · 2022Article
- A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective.International journal of molecular sciences · 2022Review
- Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants.Molecules (Basel, Switzerland) · 2022Review
- Anisotropic silk nanofiber layers as regulators of angiogenesis for optimized bone regeneration.Materials today. Bio · 2022Article
- Ultrasonographic Evaluation of the Hypospadiac Penis in Children.Frontiers in pediatrics · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the high-cost and limitations of current wound healing treatments, the search for alternative approaches or drugs, particularly from medicinal plants, is of key importance. In this study, we report anti-inflammatory and wound healing activities of the major calophyllolide (CP) compound isolated from Calophyllum inophyllum Linn. The results showed that CP had no effect on HaCaT cell viability over a range of concentrations. CP reduced fibrosis formation and effectively promoted wound closure in mouse model without causing body weight loss. The underlying molecular mechanisms of wound repair by CP was investigated. CP markedly reduced MPO activity, and increased M2 macrophage skewing, as shown by up-regulation of M2-related gene expression, which is beneficial to the wound healing process. CP treatment prevented a prolonged inflammatory process by down-regulation of the pro-inflammatory cytokines-IL-1β, IL-6, TNF-α, but up-regulation of the anti-inflammatory cytokine, IL-10. This study is the first to indicate a plausible role for CP in accelerating the process of wound healing through anti-inflammatory activity mechanisms, namely, by regulation of inflammatory cytokines, reduction in MPO, and switching of macrophages to an M2 phenotype. These findings may enable the utilization of CP as a potent therapeutic for cutaneous wound healing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.