Evidence map›Paper›PMID 29020004›Full record

ArticleNature biotechnology2017

iML1515, a knowledgebase that computes Escherichia coli traits.

Jonathan M Monk, Colton J Lloyd, Elizabeth Brunk, Nathan Mih, Anand Sastry, Zachary King, Rikiya Takeuchi, Wataru Nomura, Zhen Zhang, Hirotada Mori and 2 more

Abstract read
In one paragraph

Article in Nature biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 306 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
306citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

306 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. ACS synthetic biology · 2021
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. A systems-level atlas of carbon-response transcriptional states inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Article
  11. Article
  12. Nutrient control enables metabolic reconstruction ofbioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. Article
  15. Synthetic and systems biotechnology · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

246 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jonathan M MonkDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Colton J LloydDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Elizabeth BrunkDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0001-8578-8658
Nathan MihDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Anand SastryDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Zachary KingDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0003-1238-1499
Rikiya TakeuchiGraduate School of Biological Sciences Nara Institute of Science and Technology Ikoma, Nara, Japan.
Wataru NomuraGraduate School of Biological Sciences Nara Institute of Science and Technology Ikoma, Nara, Japan.
Zhen ZhangDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Hirotada MoriGraduate School of Biological Sciences Nara Institute of Science and Technology Ikoma, Nara, Japan.
Adam M FeistDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0002-8630-4800
Bernhard O PalssonDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0003-2357-6785

Funding

Systems Biology Approach to Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host ImmunityU01AI124316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 2016 to 2020
$10.2M
GENOMICALLY BASED MODELS FOR ANTIBIOTIC DEVELOPMENTR01GM057089 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 1998 to 2021
$6.9M
NIAID NIH HHS U01 AI124316NIGMS NIH HHS R01 GM057089
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Escherichia coliEscherichia coli ProteinsKnowledge BasesDatabase Management SystemsEscherichia coli Proteins

Identifiers

PMID29020004
PMCPMC6521705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.