ArticleNature genetics2017
Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease.
Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.
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Who cites it
110 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer's disease.Alzheimer's research & therapy · 2020Pooled it
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- Machine Learning Models Based on Histological Images from Healthy Donors Identify ImageQTLs and Predict Chronological Age.bioRxiv : the preprint server for biology · 2025Article
- Longitudinal big biological data in the AI era.Molecular systems biology · 2025Review
- BAYESIAN VARIABLE SELECTION IN A COX PROPORTIONAL HAZARDS MODEL WITH THE "SUM OF SINGLE EFFECTS" PRIOR.ArXiv · 2025Article
- Isobaric Labeling Update in MaxQuant.Journal of proteome research · 2025Article
- Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice.Molecular neurodegeneration · 2025Article
- A unified framework for cell-type-specific eQTL prioritization by integrating bulk and scRNA-seq data.American journal of human genetics · 2025Article
- Landscape of human protein-coding somatic mutations across tissues and individuals.bioRxiv : the preprint server for biology · 2025Article
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- Transcriptomic Profiling of Human Myocardium at Sudden Death to Define Vulnerable Substrate for Lethal Arrhythmias.JACC. Clinical electrophysiology · 2025Article
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- Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases.Cell genomics · 2024Article
- Housekeeping protein-coding genes interrogated with tissue and individual variations.Scientific reports · 2024Article
- Integrative cross-omics and cross-context analysis elucidates molecular links underlying genetic effects on complex traits.Nature communications · 2024Article
50 more citing papers are in PubMed but not listed here.
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Abstract
Genetic variants have been associated with myriad molecular phenotypes that provide new insight into the range of mechanisms underlying genetic traits and diseases. Identifying any particular genetic variant's cascade of effects, from molecule to individual, requires assaying multiple layers of molecular complexity. We introduce the Enhancing GTEx (eGTEx) project that extends the GTEx project to combine gene expression with additional intermediate molecular measurements on the same tissues to provide a resource for studying how genetic differences cascade through molecular phenotypes to impact human health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.