Evidence map›Paper›PMID 29019677›Full record

ArticleJournal of natural products2017

Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels.

John G Starkus, Peter Poerzgen, Kristine Layugan, Kelly Galbraith Kawabata, Jun-Ichi Goto, Sayuri Suzuki, George Myers, Michelle Kelly, Reinhold Penner, Andrea Fleig and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. [Advances in the development of transient receptor potential melastatin 2 channel inhibitors].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
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  7. Review
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  10. Article
  11. Microvascular Alterations in Alzheimer's Disease.Frontiers in cellular neuroscience · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

John G StarkusLaboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center , Honolulu, Hawaii 96813, United States.
Peter PoerzgenLaboratory of Marine Biological Chemistry, Department of Natural Sciences, Hawaii Pacific University , Kaneohe, Hawaii 96744, United States.
Kristine LayuganLaboratory of Marine Biological Chemistry, Department of Natural Sciences, Hawaii Pacific University , Kaneohe, Hawaii 96744, United States.
Kelly Galbraith KawabataLaboratory of Marine Biological Chemistry, Department of Natural Sciences, Hawaii Pacific University , Kaneohe, Hawaii 96744, United States.
Jun-Ichi GotoLaboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center , Honolulu, Hawaii 96813, United States.
Sayuri SuzukiLaboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center , Honolulu, Hawaii 96813, United States.
George MyersLaboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center , Honolulu, Hawaii 96813, United States.
Michelle KellyNational Centre for Coasts and Oceans, National Institute of Water and Atmospheric Research , Private Bag 99940, Newmarket, Auckland, 1149, New Zealand.
Reinhold PennerLaboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center , Honolulu, Hawaii 96813, United States.
Andrea FleigLaboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center , Honolulu, Hawaii 96813, United States.
F David HorgenLaboratory of Marine Biological Chemistry, Department of Natural Sciences, Hawaii Pacific University , Kaneohe, Hawaii 96744, United States.ORCID 0000-0001-9409-3030
Hawaii Pacific University · USQueen's Medical Center · USUniversity of Hawaiʻi at Mānoa · USNational Institute of Water and Atmospheric Research · NZRIKEN Center for Brain Science · JP

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
Molecular and functional properties of the TRPM2 catioin channelR01GM063954 · NIGMS · QUEEN'S MEDICAL CENTER · PI PENNER, REINHOLD · 2002 to 2010
$2.4M
Role of TRPV cation channels in mast cellsR01GM070634 · NIGMS · QUEEN'S MEDICAL CENTER · PI FLEIG, ANDREA · 2004 to 2008
$1.6M
NIGMS NIH HHS P20 GM103466NIGMS NIH HHS R01 GM063954NIGMS NIH HHS R01 GM070634
6 · The paper itself

Abstract

TRPM2 is a Ca

Indexed as

AnimalsCalciumExtracellular Signal-Regulated MAP KinasesHomosteroidsHumansMolecular StructurePhospholipases A2RatsSesterterpenesTRPM Cation ChannelsCalciumExtracellular Signal-Regulated MAP KinasesHomosteroidsPhospholipases A2scalaradialSesterterpenesTRPM Cation Channels

Identifiers

PMID29019677
PMCPMC6687308
OpenAlexW2761769453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.