SynthesisNeuropsychology review2017
Neuropsychological Measures that Predict Progression from Mild Cognitive Impairment to Alzheimer's type dementia in Older Adults: a Systematic Review and Meta-Analysis.
Synthesis in Neuropsychology review, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
158 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Cognitive markers of resilience to dementia in mild Neurocognitive Impairment: a meta- analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- The relation between cognitive functioning and activities of daily living in normal aging, mild cognitive impairment, and dementia: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Behavioral and Psychological Symptoms that Predict Cognitive Decline or Impairment in Cognitively Normal Middle-Aged or Older Adults: a Meta-Analysis.Neuropsychology review · 2020Pooled it
- Inhibitory Control Deficits in Individuals with Amnestic Mild Cognitive Impairment: a Meta-Analysis.Neuropsychology review · 2020Pooled it
- The Cognitive Profile of Mild Cognitive Impairment Due to Dementia With Lewy Bodies-An Updated Review.Frontiers in aging neuroscience · 2020Pooled it
- When does cognitive decline begin? A systematic review of change point studies on accelerated decline in cognitive and neurological outcomes preceding mild cognitive impairment, dementia, and death.Psychology and aging · 2018Pooled it
- Efficacy and Safety of Mobile App-Based Metamemory Cognitive Training for Mild Cognitive Impairment: Multicenter Randomized Clinical Trial.JMIR mHealth and uHealth · 2026Trial
- Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Trial
- Divergent associations of estimated cardiorespiratory fitness with cognitive trajectories in Chinese and U.S. middle-aged and older adults: A descriptive cross-national comparison from CHARLS and HRS.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Article
- Standardized Comparison of Clinical, Cognitive, Genetic, Neuroimaging, and Fluid Biomarkers for Predicting 24-Month Progression from Mild Cognitive Impairment to Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2026Article
- Demographically adjusted norms for a French-Quebec version of the face-name associative recognition test.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Risk of a Dementia Diagnosis in Community-Dwelling Older Adults With Normal MMSE Scores in the United States.American journal of medicine open · 2026Article
- Association between individual cerebral small vessel disease MRI markers and neuropsychological performance in amnestic mild cognitive impairment: an exploratory study.Journal of neurology · 2026Article
- Influence of testing language and aging on verbal list memory in deaf American Sign Language-English bilinguals.Neuropsychology · 2026Article
- Associations of Circadian Rhythms with Cognitive Performance in Patients with Amnestic Mild Cognitive Impairment (aMCI).Journal of clinical medicine · 2026Article
- Low Sensitivity of Neuropsychological Scales Hinder Detection of Potential Benefit of Treatments in Alzheimer's Disease: A Position Paper.European journal of neurology · 2026Review
- The predictive role of olfactory identification on episodic memory and mild cognitive impairment: Results from the CIMA-Q cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Silhouettes, number Location, and cube analysis tests from the VOSP battery reveal visual object and space perception deficits in early Alzheimer's disease.Scientific reports · 2025Article
- Explainable hierarchical machine-learning approaches for multimodal prediction of conversion from mild cognitive impairment to Alzheimer's disease.Physical and engineering sciences in medicine · 2025Article
98 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
This study aimed to determine the extent to which cognitive measures can predict progression from mild cognitive impairment (MCI) to Alzheimer's type dementia (AD), assess the predictive accuracy of different cognitive domain categories, and determine whether accuracy varies as a function of age and length of follow-up. We systematically reviewed and meta-analyzed data from longitudinal studies reporting sensitivity and specificity values for neuropsychological tests to identify individuals with MCI who will develop AD. We searched articles in Medline, Cochrane, EMBASE, PsycINFO, and the Web of Science. Methodological quality was assessed using the STARDem and QUADAS standards. Twenty-eight studies met the eligibility criteria (2365 participants) and reported predictive values from 61 neuropsychological tests with a 31-month mean follow-up. Values were pooled to provide combined accuracy for 14 cognitive domains. Many domains showed very good predictive accuracy with high sensitivity and specificity values (≥ 0.7). Verbal memory measures and many language tests yielded very high predictive accuracy. Other domains (e.g., executive functions, visual memory) showed better specificity than sensitivity. Predictive accuracy was highest when combining memory measures with a small set of other domains or when relying on broad cognitive batteries. Cognitive tests are excellent at predicting MCI individuals who will progress to dementia and should be a critical component of any toolkit intended to identify AD at the pre-dementia stage. Some tasks are remarkable as early indicators, whereas others might be used to suggest imminent progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.