ArticlePsychopharmacology2018
Sex-specific attenuation of impulsive action by progesterone in a go/no-go task for cocaine in rats.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- A ventral hippocampus to nucleus accumbens pathway regulates impulsivity in male but not female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A ventral hippocampus to nucleus accumbens pathway regulates impulsivity.bioRxiv : the preprint server for biology · 2025Article
- Regulation of risky decision making by gonadal hormones in males and females.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Sex differences in impulsivity in adult rats are mediated by organizational actions of neonatal gonadal hormones and not by hormones acting at puberty or in adulthood.Behavioural brain research · 2020Article
- Brain and Cognition for Addiction Medicine: From Prevention to Recovery Neural Substrates for Treatment of Psychostimulant-Induced Cognitive Deficits.Frontiers in psychiatry · 2019Review
- Association of exercise with smoking-related symptomatology, smoking behavior and impulsivity in men and women.Drug and alcohol dependence · 2018Article
- Addiction and Dopamine: Sex Differences and Insights from Studies of Smoking.Current opinion in behavioral sciences · 2018Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
rationalePrevious work indicated that progesterone (PRO) reduced impulsive choice for cocaine in female but not male rats (Smethells et al. Psychopharmacology 233:2999-3008, 2016). Impulsive action, typically measured by responding for a reinforcer during a signaled period of nonavailability of natural reinforcers, predicts initiation and escalation of drug use in animals and humans. The present study examined impulsive action for cocaine using PRO in male and female rats trained on a go/no-go task.
objectiveRats were trained on a go/no-go task to respond for cocaine infusions (0.4 mg/kg/inf). During the "go" component, responding was reinforced on a VI 30-s schedule, whereas during the "no-go" component, withholding a response was reinforced on a differential reinforcement of other behavior (DRO) 30-s schedule. A response during the no-go component resets the DRO timer and served as a measure of impulsive action. After baseline responding was established, rats were pretreated with vehicle (VEH) or PRO (0.5 mg/kg), and DRO resets and responding during the go component for cocaine were compared in males vs. females.
resultsDRO resets were significantly lower following PRO treatment compared to VEH in female, but not male, rats. Response rates and overall infusions during the go component were not significantly altered by PRO in either females or males.
conclusionTreatment with PRO resulted in a sex-specific reduction in impulsive action for cocaine, while not affecting cocaine self-administration.
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