ArticleCureus2017
Burden of Arrhythmias in Epilepsy Patients: A Nationwide Inpatient Analysis of 1.4 Million Hospitalizations in the United States.
Article in Cureus, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Assessing Sudden Unexpected Death in Epilepsy (SUDEP), Mortality, and Suicide in Pediatric Epilepsy from the lens of Healthcare Disparities: Data From a Scoping Review.Journal of child neurology · 2026Article
- The epileptic heart: Let's not forget to look at the atria!Epilepsia · 2025Article
- Cardiovascular Effects of Antiseizure Medications for Epilepsy.CNS drugs · 2025Review
- Management recommendations to reduce cardiac risk in chronic epilepsy.Epilepsy & behavior reports · 2025Review
- Epilepsy and the risk of adverse cardiovascular events: A nationwide cohort study.European journal of neurology · 2024Article
- Continuous cardiac monitoring in epilepsy: an implantable loop manual activation algorithm for improving ECG signal acquisition accuracy.BMC cardiovascular disorders · 2024Article
- The Epileptic Heart Syndrome: Epidemiology, pathophysiology and clinical detection.Epilepsy & behavior reports · 2024Article
- Aborted sudden cardiac death in a young patient with epilepsy and the Gorlin Goltz syndrome.Epilepsy & behavior reports · 2024Article
- The epileptic heart: Cardiac comorbidities and complications of epilepsy. Atrial and ventricular structure and function by echocardiography in individuals with epilepsy - From clinical implications to individualized assessment.Epilepsy & behavior reports · 2024Review
- The brain-heart connection: Value of concurrent ECG and EEG recordings in epilepsy management.Epilepsy & behavior reports · 2024Review
- Mapping of Neuro-Cardiac Electrophysiology: Interlinking Epilepsy and Arrhythmia.Journal of cardiovascular development and disease · 2023Review
- Epilepsy and long-term risk of arrhythmias.European heart journal · 2023Article
- QT prolongation in patients with index evaluation for seizure or epilepsy is predictive of all-cause mortality.Heart rhythm · 2022Article
- Sotalol does not interfere with the antielectroshock action of selected second-generation antiepileptic drugs in mice.Pharmacological reports : PR · 2021Article
- Arrhythmia in tumor lysis syndrome and associated in-hospital mortality: A nationwide inpatient analysis.Journal of arrhythmia · 2021Article
- Sickle cell disease-associated arrhythmias and in-hospital outcomes: Insights from the National Inpatient Sample.Journal of arrhythmia · 2020Article
- Generalized tonic-clonic seizures with post-ictal atrial fibrillation.Epilepsy & behavior reports · 2020Article
- Article
- Rising Trends in Hospitalizations for Cardiovascular Events among Young Cannabis Users (18-39 Years) without Other Substance Abuse.Medicina (Kaunas, Lithuania) · 2019Article
- The healthcare burden of bradyarrhythmias and their impact on the outcomes of 11 553 lipidoses-related hospitalizations: A nationwide inpatient contemplation.Clinical cardiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arrhythmias have been one of the common complications in epilepsy patients and have also been the reason for death. However, limited data exist about the burden and outcomes of arrhythmias by subtypes in epilepsy. Our study aims at evaluating the burden and differences in outcomes of various subtypes of arrhythmias in epilepsy patient population. The Nationwide Inpatient Sample (NIS) database from 2014 was examined for epilepsy and arrhythmias related discharges using appropriate International Classification of Disease, Ninth Revision Clinical Modification (ICD-9-CM) codes. The frequency of arrhythmias, gender differences in arrhythmia by subtypes, in-hospital outcomes and mortality predictors was analyzed. A total of 1,424,320 weighted epilepsy patients was determined and included in this study. Around 23.9% (n =277,230) patients had cardiac arrhythmias. The most frequent arrhythmias in the descending frequency were: atrial fibrillation (AFib) 9.7%, other unspecified causes 7.3%, sudden cardiac arrest (SCA) 1.4%, bundle branch block (BBB) 1.2%, ventricular tachycardia (VT) 1%. Males were more predisposed to cardiac arrhythmias compared to females (OR [odds ratio]: 1.1, p <0.001). The prevalence of most subtypes arrhythmias was higher in males. Arrhythmias were present in nearly a quarter of patients with epilepsy. Life threatening arrhythmias were more common in male patients. The length of stay (LOS) and mortality were significantly higher in epilepsy patients with arrhythmia. It is imperative to develop early diagnosis and prompt therapeutic measures to reduce this burden and poor outcomes due to concomitant arrhythmias in epilepsy patients.
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