ArticlePeerJ2017
Integration of lncRNA-miRNA-mRNA reveals novel insights into oviposition regulation in honey bees.
Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 84 citations in OpenAlex.
- Extracellular Vesicle-like Associated microRNAs in Monofloral Honeys: Molecular Characterization and Functional Pathways.International journal of molecular sciences · 2026Article
- Comparative Transcriptomic and ceRNA Network Analyses of Non-Coding and Coding RNAs in Heads ofInternational journal of molecular sciences · 2026Article
- A sterility-associated long noncoding RNA involved in honey bee caste determination and adult queen and worker fertility.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Evolution of Bees: Insights from 'Omic Studies.Genome biology and evolution · 2026Review
- The landscape and evolutionary dynamics of derived lncRNAs in insects.Communications biology · 2025Article
- Epigenetic Mechanisms inCurrent issues in molecular biology · 2025Review
- The role of gut microbiota-gonadal axis in ovary activation of Asian honey bee (Apis cerana) queens.NPJ biofilms and microbiomes · 2025Article
- The eusocial non-code: Unveiling the impact of noncoding RNAs on Hymenoptera eusocial evolution.Non-coding RNA research · 2025Review
- De Novo miRNAs fromInsects · 2024Article
- Regulation of insect behavior by non-coding RNAs.Science China. Life sciences · 2024Review
- Roles of DNA Methylation in Color Alternation of Eastern Honey Bees (International journal of molecular sciences · 2024Article
- Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.International journal of molecular sciences · 2023Review
- Article
- Systematic Characterization and Regulatory Role of lncRNAs in Asian Honey Bees Responding to Microsporidian Infestation.International journal of molecular sciences · 2023Article
- Circular RNA ame_circ_2015 Function as microRNA Sponges in Regulating Egg-Laying of Honeybees (Life (Basel, Switzerland) · 2023Article
- CircRNA Identification and CircRNA-miRNA-mRNA Network inBiology · 2022Article
- Extent and complexity of RNA processing in honey bee queen and worker caste development.iScience · 2022Article
- Abundant small RNAs in the reproductive tissues and eggs of the honey bee, Apis mellifera.BMC genomics · 2022Article
- A Novel MicroRNA and the Target Gene TAB2 Can Regulate the Process of Sucking Blood in and the Spawn Rate ofFrontiers in immunology · 2022Article
- Comparative genomics suggests local adaptations in the invasive small hive beetle.Ecology and evolution · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe honey bee (
resultsThe analysis of the RNA profiles in different oviposition phase of the queens revealed that 740 lncRNAs, 81 miRNAs and 5,481 mRNAs were differently expressed during the ovary activation; 88 lncRNAs, 13 miRNAs and 338 mRNAs were differently expressed during the oviposition inhibition process; and finally, 100 lncRNAs, four miRNAs and 497 mRNAs were differently expressed during the oviposition recovery process. In addition, functional annotation of differentially expressed RNAs revealed several pathways that are closely related to oviposition, including hippo, MAPK, notch, Wnt, mTOR, TGF-beta and FoxO signaling pathways. Furthermore, in the QTL region for ovary size, 73 differentially expressed genes and 14 differentially expressed lncRNAs were located, which are considered as candidate genes affecting ovary size and oviposition. Moreover, a core set of genes served as bridges among different miRNAs were identified through the integrated analysis of lncRNA-miRNA-mRNA network.
conclusionThe observed dramatic expression changes of coding and noncoding RNAs suggest that they may play a critical role in honey bee queens' oviposition. The identified candidate genes for oviposition activation and regulation could serve as a resource for further studies of genetic markers of oviposition in honey bees.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.