ArticleOpen heart
Left ventricular longitudinal systolic function analysed by 2D speckle-tracking echocardiography in heart failure with preserved ejection fraction: a meta-analysis.
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Who cites it
46 citing papers in PubMed.
- Type 2 diabetes in heart failure with preserved and mildly reduced ejection fraction: insights from the REDUCE-LAP-HF II trial.ESC heart failure · 2026Trial
- Characteristics Associated With Growth Differentiation Factor 15 in Heart Failure With Preserved Ejection Fraction and the Impact of Pirfenidone.Journal of the American Heart Association · 2022Trial
- On the search for the right definition of heart failure with preserved ejection fraction.Cardiology journal · 2020Trial
- Usefulness of Strain Echocardiography in Heart Failure with Preserved Ejection Fraction.Journal of clinical medicine · 2026Review
- The diagnosis and subclassification of heart failure with preserved ejection fraction: a review.Heart failure reviews · 2026Review
- Efficacy of levosimendan for acute decompensated heart failure with preserved ejection fraction in the elderly: a single-center retrospective analysis.BMC cardiovascular disorders · 2025Article
- Cardiac Imaging in the Diagnosis and Management of Heart Failure.Journal of clinical medicine · 2025Review
- Cardiovascular Manifestations of Patients with Long COVID.Diagnostics (Basel, Switzerland) · 2025Article
- Early Echocardiographic Markers in Heart Failure with Preserved Ejection Fraction.Journal of cardiovascular development and disease · 2025Review
- Non-Invasive Hemodynamic Assessment of Heart Failure With Preserved Ejection Fraction.Korean circulation journal · 2025Review
- Interpreting Diastolic Dynamics and Evaluation through Echocardiography.Life (Basel, Switzerland) · 2024Review
- A simplified approach to discriminate between healthy subjects and patients with heart failure using cardiac magnetic resonance myocardial deformation imaging.European heart journal. Imaging methods and practice · 2024Article
- The value of speckle-tracking stratified strain combined with myocardial work measurement in evaluating left ventricular function in patients with heart failure with preserved ejection fraction.Quantitative imaging in medicine and surgery · 2024Article
- Novel Strategies in Diagnosing Heart Failure with Preserved Ejection Fraction: A Comprehensive Literature Review.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Review
- Three-dimensional echocardiography and strain cardiac imaging in patients with prediabetes and type 2 diabetes mellitus.Quantitative imaging in medicine and surgery · 2023Article
- Position Statement on the Use of Myocardial Strain in Cardiology Routines by the Brazilian Society of Cardiology's Department Of Cardiovascular Imaging - 2023.Arquivos brasileiros de cardiologia · 2023Article
- Sex difference in the age-related decline of global longitudinal strain of left ventricle.Scientific reports · 2023Article
- Myocardial deformation imaging by 2D speckle tracking echocardiography for assessment of diastolic dysfunction in murine cardiopathology.Scientific reports · 2023Article
- Impaired cardiac pump function assessment with normalized cardiac power using cardiac magnetic resonance in patients with hypertrophic cardiomyopathy.Quantitative imaging in medicine and surgery · 2023Article
- Echocardiographic Features Beyond Ejection Fraction and Associated Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction.Circulation. Heart failure · 2023Article
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Authors and funding
14 authors.
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Abstract
backgroundThe purpose of this meta-analysis was to confirm if the global longitudinal systolic function of the left ventricle (LV) is altered in patients with heart failure with preserved ejection fraction (HFpEF).
methodsWe searched in different databases (Medline, Embase and Cochrane) studies that analysed LV global longitudinal systolic strain (GLS) in patients with HFpEF and in controls (such as healthy subjects or asymptomatic patients with arterial hypertension, diabetes mellitus or coronary artery disease).
resultsTwenty-two studies (2284 patients with HFpEF and 2302 controls) were included in the final analysis. Patients with HFpEF had significantly lower GLS than healthy subjects (mean -15.7% (range -12% to -18.9%) vs mean -19.9% (range -17.1% to -21.5%), weighted mean difference -4.2% (95% CI -3.3% to -5.0%), p < 0.001, respectively). In addition, patients with HFpEF had also significantly lower GLS than asymptomatic patients (mean -15.5% (range -13.4% to -18.4%) vs mean -18.3% (range -15.1% to -20.4%), weighted mean difference -2.8%(95% CI -1.9% to -3.6%), p < 0.001, respectively). In line, 10 studies showed that the rate of abnormal GLS was significantly higher in patients with HFpEF (mean 65.4% (range 37%-95%)) than in asymptomatic subjects (mean 13% (range 0%-29.6%)). Regarding the prognostic relevance of abnormal GLS in HFpEF, two multicentre studies with large sample size (447 and 348) and high number of events (115 and 177) showed that patients with abnormal GLS had worse cardiovascular (CV) outcomes than those with normal GLS (HR for CV mortality and HF hospitalisation 2.14 (95% CI 1.26 to 3.66) and 1.94 (95% CI 1.22 to 3.07)), even adjusting these analyses for multiples clinical and echocardiographic variables.
conclusionThe present meta-analysis analysing 2284 patients with HFpEF and 2302 controls confirms that the longitudinal systolic function of the LV is significantly altered in high proportion of patients with HFpEF. Further large multicentre studies with the aim to confirm the prognostic role of abnormal GLS in HFpEF are warranted.
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