ArticleFrontiers in pharmacology2017
Mechanisms of the Testis Toxicity Induced by Chronic Exposure to Mequindox.
Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Preparation and Safety Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Protective effects of aloe vera gel (aloe baberdensis Miller) on aluminum chloride-induced reproductive toxicity in male Wistar rats.JBRA assisted reproduction · 2021Article
- Review
- Does Abatacept Induce Testicular Toxicity?Archives of rheumatology · 2020Article
- Avian Stress-Related Transcriptome and Selenotranscriptome: Role during Exposure to Heavy Metals and Heat Stress.Antioxidants (Basel, Switzerland) · 2019Review
- Three-dimensional testicular organoids as novelEnvironmental epigenetics · 2019Review
- Mequindox Induced Genotoxicity and Carcinogenicity in Mice.Frontiers in pharmacology · 2018Article
- The Reproductive Toxicity of Mequindox in a Two-Generation Study in Wistar Rats.Frontiers in pharmacology · 2018Article
- Mequindox-Induced Kidney Toxicity Is Associated With Oxidative Stress and Apoptosis in the Mouse.Frontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mequindox (MEQ) is a synthetic antimicrobial agent widely used in China since the 1980s. Although the toxicity of MEQ is well recognized, its testis toxicity has not been adequately investigated. In the present study, we provide evidence that MEQ triggers oxidative stress, mitochondrion dysfunction and spermatogenesis deficiency in mice after exposure to MEQ (0, 25, 55, and 110 mg/kg in the diet) for up to 18 months. The genotoxicity and adrenal toxicity may contribute to sperm abnormalities caused by MEQ. Moreover, using LC/MS-IT-TOF analysis, two metabolites, 3-methyl-2-(1-hydroxyethyl) quinoxaline-
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