ArticleScientific reports2017
Complement Protein C3 Suppresses Axon Growth and Promotes Neuron Loss.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- Label-free proteomic profiling identifies ECM-related alterations across regeneration states in human peripheral axonal neuropathies.Journal of physiology and biochemistry · 2026Article
- Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming.Nature neuroscience · 2026Article
- Complement Activation as a Predictor of Postoperative Delirium in Elderly Spine Surgery Patients.International journal of molecular sciences · 2026Article
- Aquaporin-4 deficiency induced white matter injury via upregulated complement component 3 in cerebral small vessel disease.Journal of neuroinflammation · 2026Article
- Complement C3a Suppresses Spinal Cord Neural Stem Cell Activation by Inhibiting UCHL1 via the NF-κB p65/Nrf2 Pathway.Neuroscience bulletin · 2026Article
- Dual role of complement in neuronal repair.Frontiers in immunology · 2025Review
- Complement updates in optic neuritis.Frontiers in neurology · 2025Review
- Bioactive hydrogel synergizes neuroprotection, macrophage polarization, and angiogenesis to improve repair of traumatic brain injury.Materials today. Bio · 2024Article
- Demyelination and neurodegeneration early in experimental autoimmune encephalomyelitis contribute to functional deficits in the anterior visual pathway.Scientific reports · 2024Article
- Astrocytes: The Stars in Neurodegeneration?Biomolecules · 2024Review
- Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion.Journal of translational medicine · 2023Article
- Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.Frontiers in cellular neuroscience · 2023Article
- Old plasma dilution reduces human biological age: a clinical study.GeroScience · 2022Article
- Article
- Complementing Neuroregeneration: Deciphering the Role of Neuro-Immune Interactions in CNS Repair.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Fetal Neuroprotective Mechanism of Maternal Magnesium Sulfate: Proteomic Analysis.Journal of molecular neuroscience : MN · 2022Article
- MicroRNA-210 regulates the metabolic and inflammatory status of primary human astrocytes.Journal of neuroinflammation · 2022Article
- Characterization of Cortical Glial Scars in the Diisopropylfluorophosphate (DFP) Rat Model of Epilepsy.Frontiers in cell and developmental biology · 2022Article
- Complement Receptor 3 Pathway and NMDA Receptor 2B Subunit Involve Neuropathic Pain Associated with Spinal Cord Injury.Journal of pain research · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inflammatory response to spinal cord injury (SCI) involves localization and activation of innate and adaptive immune cells and proteins, including the complement cascade. Complement C3 is important for the classical, alternative, and lectin pathways of complement activation, and its cleavage products C3a and C3b mediate several functions in the context of inflammation, but little is known about the potential functions of C3 on regeneration and survival of injured neurons after SCI. We report that 6 weeks after dorsal hemisection with peripheral conditioning lesion, C3
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