Evidence map›Paper›PMID 29018266›Full record

ArticleThe Journal of antibiotics2018

Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics.

Philip C Hogan, Chi-Li Chen, Kristen M Mulvihill, Jonathan F Lawrence, Eric Moorhead, Jens Rickmeier, Andrew G Myers

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Philip C HoganProcess Chemistry, Macrolide Pharmaceuticals Inc., Watertown, MA, USA.
Chi-Li ChenProcess Chemistry, Macrolide Pharmaceuticals Inc., Watertown, MA, USA.
Kristen M MulvihillProcess Chemistry, Macrolide Pharmaceuticals Inc., Watertown, MA, USA.
Jonathan F LawrenceProcess Chemistry, Macrolide Pharmaceuticals Inc., Watertown, MA, USA.
Eric MoorheadProcess Chemistry, Macrolide Pharmaceuticals Inc., Watertown, MA, USA.
Jens RickmeierDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Andrew G MyersDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Harvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Key building blocks for the production of fully synthetic macrolides have been scaled-up in first time pilot plant and kilo-lab campaigns. These building blocks have supported the discovery of new macrolide antibiotics as well as ongoing preclinical studies.

Indexed as

Anti-Bacterial AgentsDrug DiscoveryDrug IndustryIndicators and ReagentsMacrolidesProtein Synthesis InhibitorsAnti-Bacterial AgentsIndicators and ReagentsMacrolidesProtein Synthesis Inhibitors

Identifiers

PMID29018266
OpenAlexW2763126200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.