ArticleScientific reports2017
Systematic Moiety Variations of Ultrashort Peptides Produce Profound Effects on Self-Assembly, Nanostructure Formation, Hydrogelation, and Phase Transition.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Ultra-Short Peptide Hydrogels as 3D Bioprinting Materials.Gels (Basel, Switzerland) · 2026Review
- Gelation behavior of short protected peptides in organic medium.Soft matter · 2025Article
- Cancer vaccines: platforms and current progress.Molecular biomedicine · 2025Review
- Fabrication of lumen-forming colorectal cancer organoids using a newly designed laminin-derived bioink.International journal of bioprinting · 2023Article
- Stimuli-Responsive Membrane Anchor Peptide Nanofoils for Tunable Membrane Association and Lipid Bilayer Fusion.ACS applied materials & interfaces · 2022Article
- Antioxidative, cytotoxic, and antibacterial properties of self-assembled glycine-histidine-based dipeptides with or without silver nanoparticles in bio-inspired film.Arhiv za higijenu rada i toksikologiju · 2022Article
- Self-Assembly of Unprotected Dipeptides into Hydrogels: Water-Channels Make the Difference.Chembiochem : a European journal of chemical biology · 2022Article
- Synthesis, Antitumor and Antibacterial Studies of New Shortened Analogues of (KLAKLAK)Molecules (Basel, Switzerland) · 2021Article
- A Global Review on Short Peptides: Frontiers and Perspectives.Molecules (Basel, Switzerland) · 2021Review
- Effective Antitumor of Orally Intestinal Targeting Penetrating Peptide-Loaded Tyroserleutide/PLGA Nanoparticles in Hepatocellular Carcinoma.International journal of nanomedicine · 2021Article
- Article
- Peptide-Peptide Co-Assembly: A Design Strategy for Functional Detection of C-peptide, A Biomarker of Diabetic Neuropathy.International journal of molecular sciences · 2020Article
- Sequence-Dependent Nanofiber Structures of Phenylalanine and Isoleucine Tripeptides.International journal of molecular sciences · 2020Article
- RGD- and VEGF-Mimetic Peptide Epitope-Functionalized Self-Assembling Peptide Hydrogels Promote Dentin-Pulp Complex Regeneration.International journal of nanomedicine · 2020Article
- Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo.International journal of nanomedicine · 2020Review
- Advancement of Peptide Nanobiotechnology via Emerging Microfluidic Technology.Micromachines · 2019Review
- Hierarchically oriented organization in supramolecular peptide crystals.Protein and peptide letters · 2019Article
- C-Terminal Residue of Ultrashort Peptides Impacts on Molecular Self-Assembly, Hydrogelation, and Interaction with Small-Molecule Drugs.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-assembly of small biomolecules is a prevalent phenomenon that is increasingly being recognised to hold the key to building complex structures from simple monomeric units. Small peptides, in particular ultrashort peptides containing up to seven amino acids, for which our laboratory has found many biomedical applications, exhibit immense potential in this regard. For next-generation applications, more intricate control is required over the self-assembly processes. We seek to find out how subtle moiety variation of peptides can affect self-assembly and nanostructure formation. To this end, we have selected a library of 54 tripeptides, derived from systematic moiety variations from seven tripeptides. Our study reveals that subtle structural changes in the tripeptides can exert profound effects on self-assembly, nanostructure formation, hydrogelation, and even phase transition of peptide nanostructures. By comparing the X-ray crystal structures of two tripeptides, acetylated leucine-leucine-glutamic acid (Ac-LLE) and acetylated tyrosine-leucine-aspartic acid (Ac-YLD), we obtained valuable insights into the structural factors that can influence the formation of supramolecular peptide structures. We believe that our results have major implications on the understanding of the factors that affect peptide self-assembly. In addition, our findings can potentially assist current computational efforts to predict and design self-assembling peptide systems for diverse biomedical applications.
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Registered trials
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