Evidence map›Paper›PMID 29018225›Full record

ArticleScientific reports2017

S1P

Ahmet Eken, Rebekka Duhen, Akhilesh K Singh, Mallory Fry, Jane H Buckner, Mariko Kita, Estelle Bettelli, Mohamed Oukka

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Lycopene Supplemented Mediterranean Diet Ameliorates Experimental Autoimmune Encephalomyelitis (EAE) in Mice and Changes Intestinal Microbiome.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmet EkenSeattle Children's Research Institute, Center for Immunity and Immunotherapies, Seattle, WA, 98101, USA.ORCID 0000-0002-5816-0686
Rebekka DuhenBenaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA.
Akhilesh K SinghSeattle Children's Research Institute, Center for Immunity and Immunotherapies, Seattle, WA, 98101, USA.
Mallory FrySeattle Children's Research Institute, Center for Immunity and Immunotherapies, Seattle, WA, 98101, USA.
Jane H BucknerBenaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA.
Mariko KitaBenaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA.
Estelle BettelliBenaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA. EBettelli@benaroyaresearch.org.
Mohamed OukkaSeattle Children's Research Institute, Center for Immunity and Immunotherapies, Seattle, WA, 98101, USA. moukka@uw.edu.

Funding

Molecular mechanisms of Th17 plasticity in MSR01NS081687 · NINDS · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BETTELLI, ESTELLE, ZIEGLER, STEVEN F · 2013 to 2017
$1.9M
Role of IL-15 and IL-23 in colitisR01AI133885 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI OUKKA, MOHAMED · 2017 to 2018
$727k
Role of Dock8 in EAER21AI124735 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI OUKKA, MOHAMED · 2016 to 2017
$530k
Role of S1P1 in the function of Regulatory T cells in Autoimmune EncephalomyelitiR56AI113906 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI OUKKA, MOHAMED · 2014 to 2014
$485k
NIAID NIH HHS R01 AI133885NIAID NIH HHS R21 AI124735NIAID NIH HHS R56 AI113906NINDS NIH HHS R01 NS081687
6 · The paper itself

Abstract

Sphingosine-1 phosphate receptor 1 (S1P

Indexed as

Gene DeletionAnimalsAutoimmunityCase-Control StudiesDisease SusceptibilityEncephalomyelitis, Autoimmune, ExperimentalFingolimod HydrochlorideHumansInflammationLymphadenopathyLymphoid TissueMiceMice, Inbred C57BLMultiple SclerosisOrgan SpecificityPhenotypeFingolimod HydrochlorideReceptors, Lysosphingolipid

Identifiers

PMID29018225
PMCPMC5635040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.