Evidence map›Paper›PMID 29018205›Full record

ArticleScientific reports2017

Genetic status of KRAS modulates the role of Neuropilin-1 in tumorigenesis.

Sneha Vivekanandhan, Lijuan Yang, Ying Cao, Engfeng Wang, Shamit K Dutta, Anil K Sharma, Debabrata Mukhopadhyay

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Neuropilin-1: A Multifaceted Target for Cancer Therapy.Current oncology (Toronto, Ont.) · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Neuropilins in the Context of Tumor Vasculature.International journal of molecular sciences · 2019
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sneha VivekanandhanDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Sciences, Rochester, MN, USA.
Lijuan YangDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Sciences, Rochester, MN, USA.
Ying CaoDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Sciences, Rochester, MN, USA.
Engfeng WangDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Sciences, Rochester, MN, USA.
Shamit K DuttaDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Sciences, Rochester, MN, USA.
Anil K SharmaDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Sciences, Rochester, MN, USA.
Debabrata MukhopadhyayDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Sciences, Rochester, MN, USA. mukhopadhyay.debabrata@mayo.edu.
Mayo Clinic · USJacksonville College · USMayo Clinic in Florida · US

Funding

Targeting Pancreatic Cancer Using Peptide Chemistry: From Bench to BedsideR01CA150190 · NCI · MAYO CLINIC ROCHESTER · PI MIERKE, DALE F, MUKHOPADHYAY, DEBABRATA · 2010 to 2021
$5.7M
Regulatory Pathways and Role of VPF/VEGF in Renal CancerR01CA078383 · NCI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2004 to 2019
$4.5M
REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCERR29CA078383 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MUKHOPADHYAY, DEBABRATA · 1998 to 2002
$383k
NCI NIH HHS R01 CA078383NCI NIH HHS R01 CA150190NCI NIH HHS R29 CA078383
6 · The paper itself

Abstract

Neuropilin-1 (NRP1), a non-tyrosine kinase receptor, is overexpressed in many cancers including pancreatic and lung cancers. Inhibition of NRP1 expression, however, has differing pro-tumor vs. anti-tumor effects, depending on the cancer types. To understand the differential role of NRP1 in tumorigenesis process, we utilized cells from two different cancer types, pancreatic and lung, each containing either wild type KRAS (KRAS

Indexed as

AnimalsCarcinogenesisCell Line, TumorCell ProliferationCell SurvivalHumansMice, SCIDMutant ProteinsNeuropilin-1OncogenesProto-Oncogene Proteins p21(ras)Signal TransductionSmad ProteinsTransforming Growth Factor betaKRAS protein, humanMutant ProteinsNeuropilin-1Proto-Oncogene Proteins p21(ras)Smad ProteinsTransforming Growth Factor beta

Identifiers

PMID29018205
PMCPMC5635066
OpenAlexW2762534429

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.