Evidence map›Paper›PMID 29018134›Full record

ArticleStroke2017

Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.

Kevin B Koronowski, Nathalie Khoury, Isabel Saul, Zachary B Loris, Charles H Cohan, Holly M Stradecki-Cohan, Kunjan R Dave, Juan I Young, Miguel A Perez-Pinzon

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Pooled it
  2. Review
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  9. SIRT1 and miR-34a as Potential Plasma Biomarkers in the Acute Phase of Ischemic Stroke.International journal of molecular and cellular medicine · 2025
    Article
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  16. NADJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
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  19. Resveratrol Preconditioning Protects Against Ischemia-Induced Synaptic Dysfunction and Cofilin Hyperactivation in the Mouse Hippocampal Slice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
  20. Resveratrol-induced SIRT1 activation inhibits glycolysis-fueled angiogenesis under rheumatoid arthritis conditions independent of HIF-1α.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kevin B KoronowskiFrom the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Nathalie KhouryFrom the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Isabel SaulFrom the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Zachary B LorisFrom the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Charles H CohanFrom the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Holly M Stradecki-CohanFrom the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Kunjan R DaveFrom the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Juan I YoungFrom the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Miguel A Perez-PinzonFrom the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL. perezpinzon@med.miami.edu.
Norwegian Womens Public Health Association · NO

Funding

ISCHEMIC PRECONDITIONING: MECHANISMS OF NEUROPROTECTIONR01NS034773 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MIGUEL A PEREZ-PINZON · 2003 to 2026
$6.7M
MECHANISMS OF NEUROPROTECTION AGAINST CARDIAC ARRESTR01NS045676 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2004 to 2024
$5.1M
Metabolic Master Regulators for Ischemic NeuroprotectionR01NS097658 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2017 to 2021
$2.1M
ISCHEMIC PRECONDITIONING: MECHANISMS OF NEUROPROTECTIONRF1NS034773 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2022 to 2022
$1.7M
ISCHEMIC PRECONDITIONING--MECHANISMS OF NEUROPROTECTIONR29NS034773 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 1997 to 2001
$267k
Neuroprotective mechanims of reseveratrol pre-conditioningF31NS089356 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI KORONOWSKI, KEVIN B · 2015 to 2017
$93k
NINDS NIH HHS F31 NS089356NINDS NIH HHS R01 NS034773NINDS NIH HHS R01 NS045676NINDS NIH HHS R01 NS097658NINDS NIH HHS R29 NS034773NINDS NIH HHS RF1 NS034773
6 · The paper itself

Abstract

background and purposeResveratrol, at least in part via SIRT1 (silent information regulator 2 homologue 1) activation, protects against cerebral ischemia when administered 2 days before injury. However, it remains unclear if SIRT1 activation must occur, and in which brain cell types, for the induction of neuroprotection. We hypothesized that neuronal SIRT1 is essential for resveratrol-induced ischemic tolerance and sought to characterize the metabolic pathways regulated by neuronal Sirt1 at the cellular level in the brain.

methodsWe assessed infarct size and functional outcome after transient 60 minute middle cerebral artery occlusion in control and inducible, neuronal-specific SIRT1 knockout mice. Nontargeted primary metabolomics analysis identified putative SIRT1-regulated pathways in brain. Glycolytic function was evaluated in acute brain slices from adult mice and primary neuronal-enriched cultures under ischemic penumbra-like conditions.

resultsResveratrol-induced neuroprotection from stroke was lost in neuronal

conclusionsOur data demonstrate that resveratrol requires neuronal SIRT1 to elicit ischemic tolerance and identify a novel role for SIRT1 in the regulation of glycolytic function in brain. Identification of robust neuroprotective mechanisms that underlie ischemia tolerance and the metabolic adaptations mediated by SIRT1 in brain are crucial for the translation of therapies in cerebral ischemia and other neurological disorders.

Indexed as

AnimalsBrain IschemiaDisease Models, AnimalGlycolysisMiceMice, KnockoutNeuronsNeuroprotective AgentsResveratrolSirtuin 1StilbenesStrokeNeuroprotective AgentsResveratrolSirt1 protein, mouseSirtuin 1Stilbenesbrainglucosemetabolomicsneuroprotectionresveratrolsirtuin 1stroke

Identifiers

PMID29018134
PMCPMC5654689
OpenAlexW2761425187

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.