Evidence map›Paper›PMID 29018050›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Jumping the Barrier: Modeling Drug Penetration across the Blood-Brain Barrier.

Cody J Peer, Cindy H Chau, William D Figg

Open access · bronzeAbstract readComment
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Cody J PeerClinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Cindy H ChauGenitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
William D FiggClinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. figgw@helix.nih.gov.
National Institutes of Health · USNational Cancer Institute · US

Funding

Using Clinical Pharmacology Principles to Develop New Anticancer TherapiesZICSC006537 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI FIGG, WILLIAM DOUGLAS · 2009 to 2025
$14.4M
Intramural NIH HHS ZIC SC006537
6 · The paper itself

Abstract

Determining the penetration of drugs across the blood-brain barrier is a significant challenge in central nervous system drug development. The use of a mechanistic physiologically based pharmacokinetic model can predict drug exposures in the brain without needing

Indexed as

GlioblastomaAdultBlood-Brain BarrierHumansPyrazolesPyrimidinesPyrimidinonesadavosertibPyrazolesPyrimidinesPyrimidinones

Identifiers

PMID29018050
PMCPMC5732885
OpenAlexW2762493662

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.