Evidence map›Paper›PMID 29018036›Full record

ArticleCirculation research2018

CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle.

Wuqiang Zhu, Meng Zhao, Saidulu Mattapally, Sifeng Chen, Jianyi Zhang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 2 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Biologics for cardiovascular diseases: from bench to bedside.Signal transduction and targeted therapy · 2026
    Review
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  7. Review
  8. Review
  9. Article
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  13. Integrative Transcriptomic and Proteomic Analysis RevealsAnimals : an open access journal from MDPI · 2025
    Article
  14. Pluripotent stem cell-based approaches for heart repair and the potential of genetic modifications.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. A spatially organizedScience advances · 2025
    Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wuqiang ZhuFrom the Department of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham (W.Z., M.Z., S.M., J.Z.); and Department of Physiology and Pathophysiology, Fudan University, Shanghai, China (M.Z., S.C.).
Meng ZhaoFrom the Department of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham (W.Z., M.Z., S.M., J.Z.); and Department of Physiology and Pathophysiology, Fudan University, Shanghai, China (M.Z., S.C.).
Saidulu MattapallyFrom the Department of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham (W.Z., M.Z., S.M., J.Z.); and Department of Physiology and Pathophysiology, Fudan University, Shanghai, China (M.Z., S.C.).
Sifeng ChenFrom the Department of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham (W.Z., M.Z., S.M., J.Z.); and Department of Physiology and Pathophysiology, Fudan University, Shanghai, China (M.Z., S.C.).
Jianyi ZhangFrom the Department of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham (W.Z., M.Z., S.M., J.Z.); and Department of Physiology and Pathophysiology, Fudan University, Shanghai, China (M.Z., S.C.). jayzhang@uab.edu.
Fudan University · CN

Funding

Integrated Cellular and Tissue Engineering for Ischemic Heart DiseaseU01HL134764 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BURSAC, NENAD, KAMP, TIMOTHY J. · 2016 to 2022
$7.7M
Supplement of HL131017: Myocardial remuscularization by cardiac patch delivery of epicardial FSTL1 and CCND2 overexpressing cardiomyocytesR01HL131017 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SERPOOSHAN, VAHID, ZHANG, JIANYI · 2016 to 2025
$5.8M
Endogenous and exogenous mechanisms that promote myocardial remuscularization in post infarction LV remodelingR01HL114120 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZHANG, JIANYI · 2012 to 2021
$5.6M
Stem Cells For Myocardial Repair: A Large Bore Magnet StudyR01HL095077 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZHANG, JIANYI · 2009 to 2017
$3.8M
Inflammatory Mediators, Cardiovascular Health, and Longevity in WomenR01HL134168 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL095077NHLBI NIH HHS R01 HL114120NHLBI NIH HHS R01 HL131017NHLBI NIH HHS R01 HL134168NHLBI NIH HHS U01 HL134764
6 · The paper itself

Abstract

rationaleThe effectiveness of transplanted, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for treatment of ischemic myocardial injury is limited by the exceptionally low engraftment rate.

objectiveTo determine whether overexpression of the cell cycle activator CCND2 (cyclin D2) in hiPSC-CMs can increase the graft size and improve myocardial recovery in a mouse model of myocardial infarction by increasing the proliferation of grafted cells. METHODS AND

resultsHuman CCND2 was delivered to hiPSCs via lentiviral-mediated gene transfection. In cultured cells, markers for cell cycle activation and proliferation were ≈3- to 7-folds higher in CCND2-overexpressing hiPSC-CMs (hiPSC-CCND2

conclusionsCCND2 overexpression activates cell cycle progression in hiPSC-CMs that results in a significant enhanced potency for myocardial repair as evidenced by remuscularization of injured myocardium. This left ventricular muscle regeneration and increased angiogenesis in border zone are accompanied by a significant improvement of left ventricular chamber function.

Indexed as

AnimalsCells, CulturedCyclin D2Gene ExpressionHeart VentriclesHEK293 CellsHumansInduced Pluripotent Stem CellsMiceMyocardial IschemiaMyocardiumMyocytes, CardiacRegenerationCCND2 protein, humanCyclin D2cell cyclecyclin D2induced pluripotent stem cellsmyocardial infarctionregeneration

Identifiers

PMID29018036
PMCPMC5756126
OpenAlexW2760931686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.