ArticleDrug metabolism and disposition: the biological fate of chemicals2017
Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in
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Article in Drug metabolism and disposition: the biological fate of chemicals, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers.Scientific reports · 2021Trial
- Orphan Cytochromes P450 as Possible Pharmacological Targets or Biomarkers in Breast Cancer.Current issues in molecular biology · 2025Review
- The Cytochrome CYP4 in Breast and Other Cancers.Biology · 2025Review
- Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism.Pharmacological reviews · 2024Review
- The fatty acid omega hydroxylase genes (CYP4 family) in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD): An RNA sequence database analysis and review.Biochemical pharmacology · 2024Review
- Design and engineering of logic genetic-enzymatic gates based on the activity of the human CYP2C9 enzyme in permeabilizedSynthetic and systems biotechnology · 2024Article
- Improved methods for the detection of heme and protoporphyrin IX adducts and quantification of heme B from cytochrome P450 containing systems.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2023Article
- Targeting Cytochrome P450 Enzymes in Ovarian Cancers: New Approaches to Tumor-Selective Intervention.Biomedicines · 2023Review
- Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers.Medicina (Kaunas, Lithuania) · 2022Article
- A CYPome-wide study reveals new potential players in the pathogenesis of Parkinson's disease.Frontiers in pharmacology · 2022Article
- Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer.Current oncology (Toronto, Ont.) · 2021Article
- Antiplatelet Therapy Combined with Anastrozole Induces Features of Partial EMT in Breast Cancer Cells and Fails to Mitigate Breast-Cancer Induced Hypercoagulation.International journal of molecular sciences · 2021Article
- Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies.Biomedicines · 2021Review
- HighFrontiers in oncology · 2021Article
- New Proluciferin Substrates for Human CYP4 Family Enzymes.Applied biochemistry and biotechnology · 2021Article
- Cytochrome 4Z1 Expression is Associated with Unfavorable Survival in Triple-Negative Breast Cancers.Breast cancer (Dove Medical Press) · 2021Article
- Cytochrome 4Z1 Expression is Associated with Poor Prognosis in Colon Cancer Patients.OncoTargets and therapy · 2021Article
- Screening of cytochrome 4Z1 expression in human non-neoplastic, pre-neoplastic and neoplastic tissues.Ecancermedicalscience · 2020Article
- Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity.Clinical and translational science · 2020Article
- Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors.Frontiers in pharmacology · 2020Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Matthew G McDonaldDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington.
Sutapa RayDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington.
Clara J AmorosiDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington.
Katherine A SitkoDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington.
John P KowalskiDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington.
Lorela PacoDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington.
Abhinav NathDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington.
Byron GallisDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington.
Rheem A TotahDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington.
Maitreya J DunhamDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington.
Douglas M FowlerDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington.
Allan E RettieDepartments of Medicinal Chemistry (M.G.M., S.R., J.P.K., L.P., A.N., B.G., R.A.T., A.E.R.), Genome Sciences (K.A.S., C.J.A., M.J.D., D.M.F.), and Bioengineering (D.M.F.), University of Washington, Seattle, Washington rettie@uw.edu.
University of Washington · US
Funding
Large-Scale Methods for Assessing the Consequences of Mutations in ProteinsR01GM109110 · NIGMS · UNIVERSITY OF WASHINGTON · PI FOWLER, DOUGLAS M · 2014 to 2021
$2.4MF-CAP: Functionalization of Variants in Clinically Actionable PharmacogenesR24GM115277 · NIGMS · UNIVERSITY OF WASHINGTON · PI FOWLER, DOUGLAS M, RETTIE, ALLAN EDWARD · 2015 to 2017
$2.2MNew Vistas in Vitamin K MetabolismR01GM109743 · NIGMS · UNIVERSITY OF WASHINGTON · PI RETTIE, ALLAN EDWARD · 2013 to 2016
$1.1MHoward Hughes Medical InstituteNIGMS NIH HHS R01 GM109110NIGMS NIH HHS R01 GM109743NIGMS NIH HHS R24 GM115277
Abstract
CYP4Z1 is an "orphan" cytochrome P450 (P450) enzyme that has provoked interest because of its hypothesized role in breast cancer through formation of the signaling molecule 20-hydroxyeicosatetraenoic acid (20-HETE). We expressed human CYP4Z1 in
Indexed as
AmidinesBreast NeoplasmsCytochrome P450 Family 4Disease ProgressionHumansHydroxyeicosatetraenoic AcidsHydroxylationInterleukin-1 Receptor-Associated KinasesLauric AcidsMass SpectrometryMicrosomes, LiverMolecular Docking SimulationOxidation-ReductionRecombinant ProteinsSaccharomyces cerevisiae20-hydroxy-5,8,11,14-eicosatetraenoic acidAmidinesCYP4Z1 protein, humanCytochrome P450 Family 4HET0016Hydroxyeicosatetraenoic AcidsInterleukin-1 Receptor-Associated KinasesLauric AcidsRecombinant Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.