Evidence map›Paper›PMID 29018025›Full record

ArticleJournal of the American Heart Association2017

Peptidyl-Prolyl Isomerase 1 Regulates Ca

Veronica Sacchi, Bingyan J Wang, Dieter Kubli, Alexander S Martinez, Jung-Kang Jin, Roberto Alvarez, Nirmala Hariharan, Christopher Glembotski, Takafumi Uchida, James S Malter and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Phosphorylation of cardiac sodium channel at Ser571 anticipates manifestations of the aging myopathy.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  3. American journal of physiology. Heart and circulatory physiology · 2022
    Article
  4. Article
  5. Peptidyl-Prolyl Isomerase 1 Regulates CaJournal of the American Heart Association · 2017
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Veronica SacchiThe San Diego Heart Research Institute and the Department of Biology, San Diego State University, San Diego, CA.
Bingyan J WangThe San Diego Heart Research Institute and the Department of Biology, San Diego State University, San Diego, CA.
Dieter KubliThe San Diego Heart Research Institute and the Department of Biology, San Diego State University, San Diego, CA.
Alexander S MartinezThe San Diego Heart Research Institute and the Department of Biology, San Diego State University, San Diego, CA.
Jung-Kang JinThe San Diego Heart Research Institute and the Department of Biology, San Diego State University, San Diego, CA.
Roberto AlvarezThe San Diego Heart Research Institute and the Department of Biology, San Diego State University, San Diego, CA.
Nirmala HariharanDepartment of Pharmacology, UC Davis, Davis, CA.
Christopher GlembotskiThe San Diego Heart Research Institute and the Department of Biology, San Diego State University, San Diego, CA.
Takafumi UchidaMolecular Enzymology, Department of Molecular Cell Science, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan.
James S MalterDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
Yijun YangCardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA.
Polina GrossCardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA.
Chen ZhangCardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA.
Steven HouserCardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA.
Marcello RotaDepartment of Physiology, Basic Science Building New York Medical College, Valhalla, NY.
Mark A SussmanThe San Diego Heart Research Institute and the Department of Biology, San Diego State University, San Diego, CA heartman4ever@icloud.com.
San Diego State University · USTemple University · USNew York Medical College · USThe University of Texas Southwestern Medical Center · USTohoku University · JPUniversity of California, Davis · US

Funding

Role of the SR/ER E3 Ubiquitin Ligase Synoviolin 1 in Cardiac HypertrophyR01HL127439 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI GLEMBOTSKI, CHRIS · 2015 to 2018
$1.7M
Harnessing the Adaptive ER Stress Response in Myocardial IschemiaR01HL135893 · NHLBI · UNIVERSITY OF ARIZONA · PI GLEMBOTSKI, CHRIS · 2017 to 2020
$1.5M
Enhanced Myocardial Repair with CardioClusters and CardioChimerasR01HL122525 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2014 to 2017
$1.5M
Stemness and Differentiation Potential Are Defined by Metabolism in Cardiac Progenitor CellsF32HL136064 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI KUBLI, DIETER ANDRE · 2017 to 2018
$122k
NHLBI NIH HHS F32 HL136064NHLBI NIH HHS R01 HL122525NHLBI NIH HHS R01 HL127439NHLBI NIH HHS R01 HL135893
6 · The paper itself

Abstract

backgroundAberrant Ca METHODS AND

resultsPin1 gene deletion or pharmacological inhibition delays cytosolic Ca

conclusionsPin1 serves as a modulator of SERCA2a and Na

Indexed as

Calcium SignalingAnimalsCalciumHeart FailureMice, Inbred C57BLMice, KnockoutMyocardial ContractionMyocytes, CardiacNIMA-Interacting Peptidylprolyl IsomeraseProtein BindingSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Calcium ExchangerTime FactorsAtp2a2 protein, mouseCalciumNIMA-Interacting Peptidylprolyl IsomerasePin1 protein, mouseSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Calcium Exchangersodium-calcium exchanger 1cardiomyocyteNa+/Ca2+ exchangepeptidyl‐prolyl isomerase 1sarcoplasmic reticulum Ca2+‐ATPase

Identifiers

PMID29018025
PMCPMC5721875
OpenAlexW2763700933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.