Trial reportJournal of the American Heart Association2017
Higher Adiposity Is Associated With Slower Cognitive Decline in Hypertensive Patients: Secondary Analysis of the China Stroke Primary Prevention Trial.
Trial report in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00794885 (Enalapril Maleate and Folic Acid Tablets for Primary Prevention of Stroke in Patients With Hypertension), which is not on this map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enalapril Maleate and Folic Acid Tablets for Primary Prevention of Stroke in Patients With Hypertension: a Post-marketing, Double-blind, Randomized Controlled Trial.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Higher Adiposity Is Associated With Slower Cognitive Decline in Hypertensive Patients: Secondary Analysis of the China Stroke Primary Prevention Trial.Journal of the American Heart Association · 2017Trial
- Cognitive impairment and associated factors among community-dwelling older adults with hypertension in tropical China.Frontiers in public health · 2026Article
- Adiposity and dementia among Chinese adults: longitudinal study in the China Health and Retirement Longitudinal Study (CHARLS).International journal of obesity (2005) · 2025Article
- Associations of dynapenic abdominal obesity and its components with cognitive impairment among hemodialysis patients.BMC geriatrics · 2025Article
- Prediction model for cognitive impairment in maintenance hemodialysis patients: the role of diabetes.Frontiers in endocrinology · 2025Article
- The association between weight-adjusted-waist index and cognitive function: the cross-sectional and longitudinal evidence from CHARLS.Frontiers in nutrition · 2025Article
- Association of physical performance with cognitive impairment in middle-aged to older haemodialysis patients: a multicentre cross-sectional observational study.The Journal of international medical research · 2024Observational
- Positive association between weight-adjusted-waist index and dementia in the Chinese population with hypertension: a cross-sectional study.BMC psychiatry · 2023Article
- Adherence to a healthy lifestyle and its association with cognitive impairment in community-dwelling older adults in Shanghai.Frontiers in public health · 2023Article
- Heterogeneity in longitudinal trajectories of cognitive performance among middle-aged and older individuals with hypertension: Growth mixture modeling across an 8-year cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Sex Differences in the Association Between Obesity and Cognitive Impairment in a Low-Income Elderly Population in Rural China: A Population-Based Cross-Sectional Study.Frontiers in neurology · 2021Article
- Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults.PloS one · 2021Article
- Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study.Frontiers in neurology · 2021Article
- Relationship Between Physical Performance and Mild Cognitive Impairment in Chinese Community-Dwelling Older Adults.Clinical interventions in aging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is a risk factor for many diseases. However, the potential association between adiposity and cognitive decline in hypertensive patients is inconclusive. We performed a secondary data analysis of the CSPPT (China Stroke Primary Prevention Trial) to examine whether adiposity is correlated with longitudinal cognitive performance in hypertensive adults. METHODS AND
resultsThe analysis included 16 791 patients in the CSPPT who received at least 2 cognitive assessments by the Mini-Mental State Examination (MMSE) during the follow-up (median, 4.5 years; interquartile range, 4.2-4.8 years). Outcomes included changes in MMSE scores and cognitive impairment (defined as MMSE score less than education-specific cutoff point). A marked reduction in MMSE scores at the final (compared with at the 1-year) follow-up was apparent in both men (n=4838; mean [SD] score, 0.41 [3.62]) and women (n=7190; mean [SD] score, 1.07 [4.61]; both
conclusionsHigher adiposity is independently associated with slower cognitive decline in Chinese hypertensive adults. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00794885 CSPPT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.