Evidence map›Paper›PMID 29017969›Full record

ArticleBrain, behavior, and immunity2018

Vigorous exercise mobilizes CD34+ hematopoietic stem cells to peripheral blood via the β

Nadia H Agha, Forrest L Baker, Hawley E Kunz, Rachel Graff, Rod Azadan, Chad Dolan, Mitzi S Laughlin, Chitra Hosing, Melissa M Markofski, Richard A Bond and 2 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07213726 (Quantification of Peripheral Hematopoietic Progenitor Cell Circulation Following Repeated Acute, Vascular Restriction Resistance Exercise Using the Delfi Tourniquet System), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07213726 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Quantification of Peripheral Hematopoietic Progenitor Cell Circulation Following Repeated Acute, Vascular Restriction Resistance Exercise Using the Delfi Tourniquet System

TypeinterventionalSponsorAndrews Research & Education FoundationRan2022 to 2026Enrolled15ConditionsBlood Flow Restriction (BFR) Training EffectsArmsDelfi Personalized Tourniquet System
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
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  7. Lessons learned from a pilot randomized clinical trial of home-based exercise prescription before allogeneic hematopoietic cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Trial
  8. βBrain, behavior, and immunity · 2018
    Trial
  9. Review
  10. Neonatal critical illness is associated with pancytopenia development in childhood.medRxiv : the preprint server for health sciences · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Exercise-induced βBrain, behavior, and immunity · 2025
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Nadia H AghaLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA.
Forrest L BakerLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA.
Hawley E KunzLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA.
Rachel GraffLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA.
Rod AzadanLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA.
Chad DolanLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA.
Mitzi S LaughlinLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA.
Chitra HosingDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Melissa M MarkofskiLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA.
Richard A BondDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA.
Catherine M BollardProgram for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System and The George Washington University, Washington D.C., USA.
Richard J SimpsonLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA; Department of Behavioral Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Nutritional Sciences, University of Arizona, Tucson, AZ, USA; Department of Pediatrics, University of Arizona, Tucson, AZ, USA. Electronic address: rjsimpson@email.arizona.edu.
University of Houston · USGeorge Washington University · USThe University of Texas MD Anderson Cancer Center · US

Funding

PR1-specific CB T cells for Patients with Myeloid MalignanciesP01CA148600 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MOLLDREM, JEFFREY J · 2011 to 2022
$24.4M
Optimizing Beta-Adrenoceptor Signaling Bias in AsthmaR01AI110007 · NIAID · DUKE UNIVERSITY · PI BOND, RICHARD AGUSTIN, PENN, RAYMOND B. · 2014 to 2018
$3.2M
CMV Infection and NK-Cell Therapy for Multiple MyelomaR21CA197527 · NCI · UNIVERSITY OF HOUSTON · PI REZVANI, KATY, SIMPSON, RICHARD J · 2016 to 2017
$390k
NCI NIH HHS P01 CA148600NCI NIH HHS R21 CA197527NIAID NIH HHS R01 AI110007
6 · The paper itself

Abstract

Acute dynamic exercise mobilizes CD34+ hematopoietic stem cells (HSCs) to the bloodstream, potentially serving as an economical adjuvant to boost the collection of HSCs from stem cell transplant donors. The mechanisms responsible for HSC mobilization with exercise are unknown but are likely due to hemodynamic perturbations, endogenous granulocyte-colony stimulating factor (G-CSF), and/or β

Indexed as

Adrenergic beta-2 Receptor AntagonistsAdultAntigens, CD34BisoprololDouble-Blind MethodExerciseFemaleGranulocyte Colony-Stimulating FactorHematopoietic Stem Cell MobilizationHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHumansMaleNadololPeripheral Blood Stem CellsReceptors, Adrenergic, beta-2Adrenergic beta-2 Receptor AntagonistsAntigens, CD34BisoprololGranulocyte Colony-Stimulating FactorNadololReceptors, Adrenergic, beta-2BisoprololCD133Exercise immunologyExercise intensityGranulocyte colony stimulating factor (G-CSF)Hematopoietic stem cell transplantationNadololProgenitor cellsβ-AR blockade

Identifiers

PMID29017969
PMCPMC6980177
OpenAlexW2762571374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.