ArticleCardiovascular diabetology2017
Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients.
Article in Cardiovascular diabetology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Long-term HbA1c variability and macro-/micro-vascular complications in type 2 diabetes mellitus: a meta-analysis update.Acta diabetologica · 2023Pooled it
- Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report.Cardiovascular diabetology · 2018Trial
- Development and validation of a nomogram model for predicting cardiac autonomic neuropathy in patients with diabetes.Frontiers in endocrinology · 2026Article
- Whether coagulation dysfunction influences the onset and progression of diabetic peripheral neuropathy: A multicenter study in middle-aged and aged patients with type 2 diabetes.CNS neuroscience & therapeutics · 2024Article
- Clinical and pathological significance of Orai1 channel expression in human diabetic nephropathy.Kidney research and clinical practice · 2024Article
- Analysis of Factors Related to Type 2 Diabetic Peripheral Neuropathy Based on Flash Glucose Monitoring System.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Glycated albumin and HbA1c as markers of lower extremity disease inUS adults with and without diabetes.Diabetes research and clinical practice · 2022Article
- Visit-to-visit variability of glycated albumin was associated with incidence or progression of lower extremity atherosclerotic disease.Cardiovascular diabetology · 2020Article
- Estimation of homeostatic dysregulation and frailty using biomarker variability: a principal component analysis of hemodialysis patients.Scientific reports · 2020Article
- Association between visit-to-visit variability of HbADiabetologia · 2020Article
- Progression of cardiovascular autonomic neuropathy and cardiovascular disease in type 2 diabetes.Cardiovascular diabetology · 2018Article
- Visit-to-visit HbA1c variability is inversely related to baroreflex sensitivity independently of HbA1c value in type 2 diabetes.Cardiovascular diabetology · 2018Article
- HbA1c variability and diabetic peripheral neuropathy in type 2 diabetic patients.Cardiovascular diabetology · 2018Observational
- Long-term visit-to-visit glycemic variability as predictor of micro- and macrovascular complications in patients with type 2 diabetes: The Rio de Janeiro Type 2 Diabetes Cohort Study.Cardiovascular diabetology · 2018Observational
- Postload Glycated Albumin as an Alternate Measure for Diabetes Screening in a Chinese Population.Journal of diabetes research · 2018Article
- Evaluation of the relationship between cardiac autonomic function and glucose variability and HOMA-IR in prediabetes.Diabetes & vascular disease researchArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated whether glycated albumin (GA) and its variability are associated with cardiovascular autonomic neuropathy (CAN) and further compared their associations with glycated hemoglobin (HbA1c).
methodsThis retrospective longitudinal study included 498 type 2 diabetic patients without CAN. CAN was defined as at least two abnormal results in parasympathetic tests or presence of orthostatic hypotension. The mean, standard deviation (SD), and coefficient of variance (CV) were calculated from consecutively measured GA (median 7 times) and HbA1c levels (median 8 times) over 2 years. Logistic regression analysis was used to compare the associations between CAN and GA- or HbA1c-related parameters. Receiver operating characteristic (ROC) curve analysis was used to compare the predictive power for CAN between GA- and HbA1c-related parameters.
resultsA total of 53 subjects (10.6%) developed CAN over 2 years. The mean, SD, and CV of GA or HbA1c were significantly higher in subjects with CAN. Higher mean GA and GA variability were associated with the risk of developing CAN, independent of conventional risk factors and HbA1c. In ROC curve analysis, the SD and CV of GA showed higher predictive value for CAN compared to the SD and CV of HbA1c, whereas the predictive value of mean GA did not differ from that of mean HbA1c. The mean, SD, and CV of GA showed additive predictive power to detect CAN development along with mean HbA1c.
conclusionsHigher serum GA and its variability are significantly associated with the risk of developing CAN. Serum GA might be a useful indicator for diabetic complications and can enhance HbA1c's modest clinical prediction for CAN.
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