ArticleBMC pregnancy and childbirth2017
Association between very advanced maternal age and adverse pregnancy outcomes: a cross sectional Japanese study.
Article in BMC pregnancy and childbirth, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Maternal and perinatal complications according to maternal age: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022Pooled it
- Clinical Practice Guidelines for Prenatal Aneuploidy Screening and Diagnostic Testing from Korean Society of Maternal-Fetal Medicine: (2) Invasive Diagnostic Testing for Fetal Chromosomal Abnormalities.Journal of Korean medical science · 2021Guideline
- Interactive Effects of Parental Age on Adverse Birth Outcomes in Japan: An Investigation of Nationwide Birth Data.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026Article
- Pregnancy Outcome in Women Aged 40 Years and Above: A Cross Sectional Study.Journal of obstetrics and gynaecology of India · 2026Article
- Association between gestational weight gain and adverse pregnancy outcomes in advanced maternal age: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Timing of First Cuddling After Preterm Birth Improved Over Five Decades, While Delays Were Linked to Negative Maternal Experiences.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Reproduction outcomes and prognostic significance of pregnancy after nasopharyngeal carcinoma treatment.Annals of medicine · 2025Article
- Advanced maternal age increases the risk of adverse neonatal outcomes: a comparative study in Ethiopia.BMC pregnancy and childbirth · 2025Article
- Increased vaginalmSystems · 2025Article
- Maternal and neonatal outcomes in full-term pregnancies of very advanced maternal age: a Japanese single-center retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Pregnancy outcomes among women near the end of reproductive age.BMC pregnancy and childbirth · 2025Article
- Delaying Motherhood-An Increasingly Common but Risky Trend in High-Income Countries.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study.Journal of diabetes investigation · 2025Article
- Article
- Influencing Factor Analysis and Prediction Model of Emergency Caesarean Delivery for Advanced-Age Nulliparous Women at the Time of Hospitalization.Journal of family & reproductive health · 2024Article
- Birth outcomes of advanced maternal age pregnancies.Central European journal of public health · 2024Article
- Adverse maternal outcomes and associated factors among mothers of advanced age delivering at a tertiary hospital, southwestern Uganda: a cross-sectional study.BMC pregnancy and childbirth · 2024Article
- Unplanned cesarean sections in advanced maternal age: A predictive model.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Determinants of advanced age pregnancy in Ethiopian; multi-level analysis of Ethiopian demographic health survey 2016.PloS one · 2024Article
- The Association between Advanced Maternal Age and the Manifestations of Preeclampsia with Severe Features.Journal of clinical medicine · 2023Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile several studies have demonstrated the increased risk of pregnancy complications for women of advanced age, few studies have focused on women with very advanced age (≥ 45), despite the increasing rate of pregnancy among such women. Furthermore, how such risks of increase in age differ by maternal characteristics are also poorly understood. Thus, we aimed to clarify pregnant outcomes among women with very advanced age and how the effect of age differs by method of conception and parity.
methodsWe used the national multicenter Japan Society of Obstetrics and Gynecology perinatal database, including 365,417 women aged 30 years or older who delivered a singleton between 2005 and 2011. We divided women into four groups based on age (years): 30-34, 35-39, 40-44, and ≥45, and compared risk of adverse birth outcomes between the groups using Poisson regression. Effect modification by parity and use of assisted reproductive technology (ART) was also evaluated.
resultsCompared with women aged 30-34 years, women aged 45 or older had higher risk of emergency cesarean delivery [adjusted risk ratio (aRR): 1.77, 95% confidence interval (95% CI): 1.58-1.99], preeclampsia (aRR: 1.86, 95% CI: 1.43-2.42), severe preeclampsia (aRR: 2.03, 95% CI: 1.31-3.13), placenta previa (aRR: 2.17, 95% CI: 1.60-2.95), and preterm birth (aRR: 1.20, 95% CI: 1.04-1.39). The effect of older age on risk of emergency cesarean section, preeclampsia, and preterm birth were significantly greater among those who conceived naturally compared to those who conceived by ART. The effect on emergency cesarean section was stronger among primiparous women, whereas the risk of preeclampsia associated with older age was significantly greater among multiparous women.
conclusionsVery advanced maternal age (≥ 45) was related to greater risk for adverse birth outcomes compared to younger women, especially for maternal complications including cesarean section, preeclampsia, severe preeclampsia, and placenta previa. The magnitude of the influence of age also differed by conception method and by parity.
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