ArticleJournal of neurotrauma2018
Acute Clinical Predictors of Symptom Recovery in Emergency Department Patients with Uncomplicated Mild Traumatic Brain Injury or Non-Traumatic Brain Injuries.
Article in Journal of neurotrauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Examination of Reaction Time Deficits Following Concussion: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Review
- Functional Connectivity Patterns Following Mild Traumatic Brain Injury and the Association With Longitudinal Cognitive Function.Human brain mapping · 2025Article
- Association of Subacute Mild Traumatic Brain Injury Symptoms With Long-Term Persistent Symptoms, Functional Limitations, and Quality of Life.Neurology · 2025Article
- Neuromechanical Models of Mild Traumatic Brain Injury Conditioned on Reaction Time: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- The Role of Sex and Gender in Precision Emergency Medicine: A Scoping Review and Proposed Hierarchy.Clinical therapeutics · 2024Article
- Using machine learning to discover traumatic brain injury patient phenotypes: national concussion surveillance system Pilot.Brain injury · 2024Article
- Use of the Buffalo Concussion Treadmill Test in community adult patients with mild traumatic brain injury.PM & R : the journal of injury, function, and rehabilitation · 2024Observational
- Dual statistical models link baseline visual attention measure to risk for significant symptomatic concussion in sports.Concussion (London, England) · 2023Article
- Functional Recovery, Symptoms, and Quality of Life 1 to 5 Years After Traumatic Brain Injury.JAMA network open · 2023Article
- Network analysis and relationship of symptom factors to functional outcomes and quality of life following mild traumatic brain injury: a TRACK-TBI study.Frontiers in neurology · 2023Article
- Differing associations between measures of somatic symptom reporting, personality, and mild traumatic brain injury (mTBI).The Clinical neuropsychologist · 2022Article
- Article
- Editorial: Behavioral outcomes of traumatic brain injury.Frontiers in behavioral neuroscience · 2022Article
- Article
- Concussion-Recovery Trajectories Among Tactical Athletes: Results From the CARE Consortium.Journal of athletic training · 2020Article
- Towards the Development of an Integrative, Evidence-Based Suite of Indicators for the Prediction of Outcome Following Mild Traumatic Brain Injury: Results from a Pilot Study.Brain sciences · 2020Article
- Frequency of Primary Neck Pain in Mild Traumatic Brain Injury/Concussion Patients.Archives of physical medicine and rehabilitation · 2020Article
- The Role of Speech-Language Pathology in an Interdisciplinary Care Model for Persistent Symptomatology of Mild Traumatic Brain Injury.Seminars in speech and language · 2019Article
- Cognitive Impairment Following Acute Mild Traumatic Brain Injury.Frontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
There is a subset of patients with mild traumatic brain injury (mTBI) who report persistent symptoms that impair their functioning and quality of life. Being able to predict which patients will experience prolonged symptom recovery would help clinicians target resources for clinical follow-up to those most in need, and would facilitate research to develop precision medicine treatments for mTBI. The purpose of this study was to investigate the predictors of symptom recovery in a prospective sample of emergency department trauma patients with either mTBI or non-mTBI injuries. Subjects were examined at several time points from within 72 h to 45 days post-injury. We quantified and compared the value of a variety of demographic, injury, and clinical assessment (symptom, neurocognitive) variables for predicting self-reported symptom duration in both mTBI (n = 89) and trauma control (n = 73) patients. Several injury-related and neuropsychological variables assessed acutely (< 72 h) post-injury predicted symptom duration, particularly loss of consciousness (mTBI group), acute somatic symptom burden (both groups), and acute reaction time (both groups), with reasonably good model fit when including all of these variables (area under the receiver operating characteristic curve [AUC] = 0.76). Incorporating self-reported litigation involvement modestly increased prediction further (AUC = 0.80). The results highlight the multifactorial nature of mTBI recovery, and injury recovery more generally, and the need to incorporate a variety of variables to achieve adequate prediction. Further research to improve this model and validate it in new and more diverse trauma samples will be useful to build a neurobiopsychosocial model of recovery that informs treatment development.
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Registered trials
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