SynthesisNeuro-oncology2018
Clinical characteristics associated with postoperative seizure control in adult low-grade gliomas: a systematic review and meta-analysis.
Synthesis in Neuro-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- EANS-EANO guidelines on the extent of resection in gliomas.Neuro-oncology · 2026Guideline
- Development of an integrated predictive model for postoperative glioma-related epilepsy using gene-signature and clinical data.BMC cancer · 2023Trial
- Brain regions associated with frequent occurrences of seizures related to low-grade gliomas: a voxel-level evidence.Frontiers in human neuroscience · 2026Article
- Leveraging pathological markers of lower grade glioma to predict the occurrence of secondary epilepsy, a retrospective study.Scientific reports · 2025Article
- Voxel-based mapping of postoperative epilepsy risk in glioma patients: supplementary motor area and limbic system correlations.Frontiers in neurology · 2025Article
- Prognostic modeling of glioma using epilepsy-related genes highlights PAX3 as a regulator of migration and vorinostat sensitivity.Frontiers in neurology · 2025Article
- Gene mutations linked to drug-resistant epilepsy in astrocytoma.Frontiers in neurology · 2025Article
- IL-6 is associated with poor seizure control in low-grade glioma patients undergoing primary resection.iScience · 2024Article
- Real-world cost- effectiveness analysis: Tumor Treating Fields for newly diagnosed glioblastoma in China.Journal of neuro-oncology · 2024Article
- Efficacy of Personalized Postoperative Epilepsy Management in Patients with Glioblastoma Utilizing IDH1 Gene Assessment.Neuropsychiatric disease and treatment · 2024Article
- Construction and validation of an immune infiltration-related risk model for predicting prognosis and immunotherapy response in low grade glioma.BMC cancer · 2023Article
- Multiparametric mapping of white matter reorganizations in patients with frontal glioma-related epilepsy.CNS neuroscience & therapeutics · 2023Article
- Predictors of seizure outcomes in patients with diffuse low-grade glioma-related epilepsy after complete glioma removal.CNS neuroscience & therapeutics · 2023Article
- The long-term surgical outcomes of low-grade epilepsy-associated neuroepithelial tumors.Epilepsia open · 2022Article
- Seizures in patients with IDH-mutated lower grade gliomas.Journal of neuro-oncology · 2022Article
- The cognitive functions and seizure outcomes of patients with low-grade epilepsy-associated neuroepithelial tumors.Journal of neuro-oncology · 2022Article
- The persistence of seizures after tumor resection negatively affects survival in low-grade glioma patients: a clinical retrospective study.Journal of neurology · 2022Article
- Resective surgery for patients with frontal lobe diffuse low-grade glioma-related epilepsy: predictors of seizure outcomes.Therapeutic advances in chronic disease · 2022Article
- Low-grade epilepsy-associated neuroepithelial tumors: Tumor spectrum and diagnosis based on genetic alterations.Frontiers in neuroscience · 2022Review
- Chinese guideline on the application of anti-seizure medications in the perioperative period of supratentorial craniocerebral surgery.Therapeutic advances in neurological disorders · 2022Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Epilepsy is the most common symptom in patients with supratentorial low-grade gliomas (LGGs), which adversely affects the patient's quality of life. Poor seizure control with anti-epileptic therapy is an indication for surgery in these patients. Recent studies have sought to identify predictors of postoperative seizure control after surgical resection of LGG; gross total resection was shown to be a significant predictor in this respect. However, the prognostic value of other factors is not clear. Methods: We performed a systematic review and meta-analysis of 23 studies with a combined study population of 2641 patients with LGG, in order to identify potential factors associated with favorable postoperative seizure control. Data were extracted on age and sex of patient, tumor location, tumor histology, type of seizure, seizure duration, extent of resection, and imaging characteristics. Results: Patients ≥45 years of age achieved better postoperative seizure control (risk ratio [RR], 0.89; 95% CI, 0.81-0.99). Focal seizures were associated with poor seizure control (RR, 1.32; 95% CI, 1.18-1.49) compared with generalized seizures (RR, 0.77; 95% CI, 0.68-0.87). Prolonged history of seizures (≥1 y) had a negative impact on postoperative seizure control (RR, 1.22; 95% CI, 1.10-1.34). Gross total resection was superior to subtotal resection with respect to postoperative seizure control (RR, 0.68; 95% CI, 0.63-0.73). Conclusions: This systematic review and meta-analysis identified predictors of postoperative seizure control in patients undergoing surgical resection of LGGs. Our results provide a reference for clinical treatment of LGG-related epilepsy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.