Evidence map›Paper›PMID 29016858›Full record

SynthesisHuman molecular genetics2017

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium.

Gemma C Sharp, Lucas A Salas, Claire Monnereau, Catherine Allard, Paul Yousefi, Todd M Everson, Jon Bohlin, Zongli Xu, Rae-Chi Huang, Sarah E Reese and 75 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human molecular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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  14. Epigenome-wide meta-analysis of DNA methylation and childhood asthma.The Journal of allergy and clinical immunology · 2019
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

85 authors.

Gemma C SharpMRC Integrative Epidemiology Unit.
Lucas A SalasISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Claire MonnereauThe Generation R Study Group.
Catherine AllardCentre de Recherche du Centre Hospitalier, Université de Sherbrooke, QC, Canada.
Paul YousefiCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley.
Todd M EversonDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Jon BohlinDepartment of Infection Epidemiology and Modeling, Norwegian Institute of Public Health, Oslo, Norway.
Zongli XuEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Rae-Chi HuangTelethon Kids Institute, University of Western Australia, Crawley, WA 6009, Australia.
Sarah E ReeseNational Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Cheng-Jian XuDepartment of Pulmonology, GRIAC Research Institute.
Nour BaïzEpidemiology of Allergic and Respiratory Diseases Department (EPAR), Sorbonne Université, UPMC Univ Paris 06, INSERM, Pierre Louis Institute of Epidemiology and Public Health, Saint-Antoine Medical School, Paris, France.
Cathrine HoyoDepartment of Biological Sciences.
Golareh AghaDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Ritu RoyUniversity of California San Francisco, CA, USA.
John W HollowayHuman Development & Health, Faculty of Medicine, University of Southampton, UK.
Akram GhantousEpigenetics Group, International Agency for Research on Cancer, Lyon, France.
Simon K MeridInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Kelly M BakulskiDepartment of Epidemiology, School of Public Health, University of Michigan, MI, USA.
Leanne K KüpersMRC Integrative Epidemiology Unit.
Hongmei ZhangDivision of Epidemiology, Biostatistics, and Environmental Health Sciences, School of Public Health, University of Memphis, Memphis, TN, USA.
Rebecca C RichmondMRC Integrative Epidemiology Unit.
Christian M PageDepartment of Non-Communicable Disease, Norwegian Institute of Public Health, Oslo, Norway.
Liesbeth DuijtsThe Generation R Study Group.
Rolv T LieDepartment of Global Public Health and Primary Care, University of Bergen, Norway.
Phillip E MeltonThe Curtin UWA Centre for Genetic Origins of Health and Disease, Faculty of Health Sciences, Curtin University Health Sciences, Curtin University and Faculty of Medicine Dentistry & Health Sciences, The University of Western Australia, Perth, Australia.
Judith M VonkDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, GRIAC Research Institute Groningen, The Netherlands.
Ellen A NohrResearch Unit for Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
ClarLynda Williams-DeVaneDepartment of Biological & Biomedical Sciences, North Carolina Central University, Durham, NC, USA.
Karen HuenCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley.
Sheryl L Rifas-ShimanObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, USA.
Carlos Ruiz-ArenasISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Semira GonsethDepartment of Epidemiology and Biostatistics, University of California San Francisco, CA, USA.
Faisal I RezwanHuman Development & Health, Faculty of Medicine, University of Southampton, UK.
Zdenko HercegEpigenetics Group, International Agency for Research on Cancer, Lyon, France.
Sandra EkströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Lisa CroenDivision of Research, Kaiser Permanente Northern California, CA, UDA.
Fahimeh FalahiDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Patrice PerronCentre de Recherche du Centre Hospitalier, Université de Sherbrooke, QC, Canada.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Bilal M QuraishiDivision of Epidemiology, Biostatistics, and Environmental Health Sciences, School of Public Health, University of Memphis, Memphis, TN, USA.
Matthew SudermanMRC Integrative Epidemiology Unit.
Maria C MagnusMRC Integrative Epidemiology Unit.
Vincent W V JaddoeThe Generation R Study Group.
Jack A TaylorEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Denise AndersonTelethon Kids Institute, University of Western Australia, Crawley, WA 6009, Australia.
Shanshan ZhaoNational Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Henriette A SmitJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
Michele J JoseyDepartment of Biological & Biomedical Sciences, North Carolina Central University, Durham, NC, USA.
Asa BradmanCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Mariona BustamanteISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Siri E HåbergDomain of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Irva Hertz-PicciottoDepartment of Public Health, School of Medicine, University of California, Davis, CA, USA.
Craig NewschafferAJ Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
Eva CorpeleijnDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Luigi BouchardDepartment of Biochemistry, Université de Sherbrooke, QC, Canada.
Debbie A LawlorMRC Integrative Epidemiology Unit.
Rachel L MaguireDepartment of Biological Sciences.
Lisa F BarcellosCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley.
George Davey SmithMRC Integrative Epidemiology Unit.
Brenda EskenaziCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley.
Wilfried KarmausDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Carmen J MarsitDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Marie-France HivertObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
M Daniele FallinDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Monica C Munthe-KaasDepartment of Pediatric and Adolescent Medicine, Oslo University Hospital, Norway.
Hasan ArshadClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Joseph L WiemelsDepartment of Epidemiology and Biostatistics, University of California San Francisco, CA, USA.
Isabella Annesi-MaesanoEpidemiology of Allergic and Respiratory Diseases Department (EPAR), Sorbonne Université, UPMC Univ Paris 06, INSERM, Pierre Louis Institute of Epidemiology and Public Health, Saint-Antoine Medical School, Paris, France.
Martine VrijheidISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Emily OkenObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, USA.
Nina HollandCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley.
Susan K MurphyDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
Thorkild I A SørensenMRC Integrative Epidemiology Unit.
Gerard H KoppelmanDepartment of Paediatric Pulmonology and Paediatric Allergy, University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, GRIAC Research Institute, Groningen, the Netherlands.
John P NewnhamSchool of Women's and Infants' Health, The University of Western Australia, Crawley, WA 6009, Australia.
Allen J WilcoxEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Wenche NystadDepartment of Non-Communicable Disease, Norwegian Institute of Public Health, Oslo, Norway.
Stephanie J LondonNational Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Janine F FelixThe Generation R Study Group.
Caroline L ReltonMRC Integrative Epidemiology Unit.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2013 to 2022
$23.7M
Environmental Exposure and DNA DamageZIAES049032 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, JACK A · 2009 to 2022
$13.4M
Interdisciplinary Research Careers in Women's HealthK12HD043446 · NICHD · DUKE UNIVERSITY · PI AMUNDSEN, CINDY · 2002 to 2023
$9.6M
Genetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8M
Project 3: Placental Biomarkers of Exposure and Outcome (Marsit)P01ES022832 · NIEHS · DARTMOUTH COLLEGE · PI MURRAY, CAROLYN J · 2013 to 2018
$4.7M
Epidemiologic Study Of Reproductive Outcomes And Environmental ExposuresZIAES044003 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WILCOX, ALLEN J · 2009 to 2020
$4.7M
Environment, Imprinting, and NeurodevelopmentR01ES022223 · NIEHS · EMORY UNIVERSITY · PI CHEN, JIA, MARSIT, CARMEN JOSEPH · 2013 to 2017
$4.3M
Project 3 - Prenatal Exposures, Constitutive Genetics, DNA Methylation & Childhood LeukemiaP50ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2015 to 2019
$3.8M
Project 3: Prenatal Exposure, DNA Methylation & Childhood LeukemiaP01ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2009 to 2013
$3.7M
Does epigenetic methylation explain the gender-switch in adolescent asthma?R01AI121226 · NIAID · UNIVERSITY OF MEMPHIS · PI HOLLOWAY, JOHN W, ZHANG, HONGMEI · 2016 to 2020
$3.2M
Prenatal exposure to metals and risk for Autism Spectrum Disorder in MARBLES and EARLIR01ES025531 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI VOLK, HEATHER E · 2016 to 2020
$3.2M
European Research Council 648916Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013/5NCI NIH HHS R25 CA134286NIAID NIH HHS R01 AI121226NICHD NIH HHS K12 HD043446NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK103246NIEHS NIH HHS P01 ES018172NIEHS NIH HHS P01 ES022832NIEHS NIH HHS P50 ES018172NIEHS NIH HHS R01 ES021369NIEHS NIH HHS R01 ES022223NIEHS NIH HHS R01 ES025531NIEHS NIH HHS R24 ES028507NIGMS NIH HHS P20 GM104416NIMH NIH HHS R01 MH094609World Health Organization 001
6 · The paper itself

Abstract

Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs), we meta-analysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents. In newborns, maternal BMI was associated with small (<0.2% per BMI unit (1 kg/m2), P < 1.06 × 10-7) methylation variation at 9,044 sites throughout the genome. Adjustment for estimated cell proportions greatly attenuated the number of significant CpGs to 104, including 86 sites common to the unadjusted model. At 72/86 sites, the direction of the association was the same in newborns and adolescents, suggesting persistence of signals. However, we found evidence for acausal intrauterine effect of maternal BMI on newborn methylation at just 8/86 sites. In conclusion, this well-powered analysis identified robust associations between maternal adiposity and variations in newborn blood DNA methylation, but these small effects may be better explained by genetic or lifestyle factors than a causal intrauterine mechanism. This highlights the need for large-scale collaborative approaches and the application of causal inference techniques in epigenetic epidemiology.

Indexed as

AdultBody Mass IndexCohort StudiesDNA MethylationEpigenesis, GeneticEpigenomicsFemaleHumansInfant, NewbornMaleMaternal InheritanceMothersObesityPregnancyPregnancy OutcomePrenatal Exposure Delayed Effects

Identifiers

PMID29016858
PMCPMC5656174

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.