ArticlePloS one2017
Characterization of the Rotating Exercise Quantification System (REQS), a novel Drosophila exercise quantification apparatus.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
- The impact of exercise on protein levels in Drosophila melanogaster.Biology open · 2026Article
- FLEX: Flight Exercise Training Protocol for the Fruit Fly Drosophila.Journal of visualized experiments : JoVE · 2025Article
- Unpredictable disturbance and its effects on activity behavior and lifespan in Drosophila melanogaster.Biology open · 2025Article
- Review
- Exercise-induced changes in climbing performance.Royal Society open science · 2021Article
- GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise.Scientific reports · 2021Article
- Heat shock proteins and small nucleolar RNAs are dysregulated in a Drosophila model for feline hypertrophic cardiomyopathy.G3 (Bethesda, Md.) · 2021Article
- Preference and detrimental effects of high fat, sugar, and salt diet in wild-caught Drosophila simulans are reversed by flight exercise.FASEB bioAdvances · 2021Article
- Variation in mobility and exercise adaptations between Drosophila species.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Genetic Networks Underlying Natural Variation in Basal and Induced Activity Levels inG3 (Bethesda, Md.) · 2020Article
- The Role of Muscle in Insect Energy Homeostasis.Frontiers in physiology · 2020Review
- The TreadWheel: Interval Training Protocol for Gently Induced Exercise in Drosophila melanogaster.Journal of visualized experiments : JoVE · 2018Article
- Measuring Exercise Levels in Drosophila melanogaster Using the Rotating Exercise Quantification System (REQS).Journal of visualized experiments : JoVE · 2018Article
- Article
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2 authors at 1 institution in 1 country.
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Abstract
Obesity is a disease that has reached epidemic proportions in the United States and has prompted international legislation in an attempt to curtail its prevalence. Despite the fact that one of the most prescribed treatment options for obesity is exercise, the genetic mechanisms underlying exercise response in individuals are still largely unknown. The fruit fly Drosophila melanogaster is a promising new model for studying exercise genetics. Currently, the lack of an accurate method to quantify the amount of exercise performed by the animals is limiting the utility of the Drosophila model for exercise genetics research. To address this limitation, we developed the Rotational Exercise Quantification System (REQS), a novel apparatus that is able to simultaneously induce exercise in flies while recording their activity levels. Thus, the REQS provides a method to standardize Drosophila exercise and ensure that all animals irrespective of genotype and sex experience the same level of exercise. Here, we provide a basic characterization of the REQS, validate its measurements using video-tracking technology, illustrate its potential use by presenting a comparison of two different exercise regimes, and demonstrate that it can be used to detect genotype-dependent variation in activity levels.
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