ArticlePloS one2017
Quantification of carious pathogens in the interdental microbiota of young caries-free adults.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Improved Plaque-Induced Gingivitis in Students Using Calibrated Interdental Brushes: Results of a 3-Month Multicenter Educational Intervention.Journal of clinical medicine · 2025Article
- Article
- Periodontal pathogens of the interdental microbiota in a 3 months pregnant population with an intact periodontium.Frontiers in microbiology · 2023Article
- Interdental biofilm reduction and composition after use of an activated and inactivated side-to-side toothbrush - a proof-of-principle clinical study.Clinical oral investigations · 2022Article
- Diversity of site-specific microbes of occlusal and proximal lesions in severe- early childhood caries (S-ECC).Journal of oral microbiology · 2022Article
- Microbiome of Saliva and Plaque in Children According to Age and Dental Caries Experience.Diagnostics (Basel, Switzerland) · 2021Article
- Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review.International journal of environmental research and public health · 2021Article
- Cariogenic Biofilm: Pathology-Related Phenotypes and Targeted Therapy.Microorganisms · 2021Review
- Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients: A Cross-Sectional Study.Frontiers in microbiology · 2021Article
- Profuse diversity and acidogenicity of theJournal of oral microbiology · 2021Article
- The composition of microbial communities in inflammatory periodontal diseases in young adults Tatars.AIMS microbiology · 2021Article
- Regulating Oral Biofilm from Cariogenic State to Non-Cariogenic State via Novel Combination of Bioactive Therapeutic Composite and Gene-Knockout.Microorganisms · 2020Article
- Management ofJournal of clinical medicine · 2020Review
- High-throughput DNA sequencing of microbiota at interproximal sites.Journal of oral microbiology · 2020Article
- Microbiota of interdental space of adolescents according to Risk of Caries: A cross-sectional study protocol.Contemporary clinical trials communications · 2019Article
- Bacterial Colonization and Tissue Compatibility of Denture Base Resins.Dentistry journal · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe majority of caries lesions in adults occur on the proximal tooth surfaces of the posterior teeth. A comprehensive study of the composition of the oral microbiota is fundamental for a better understanding of the etiology of interdental caries.
methodsTwenty-five caries-free subjects (20-35 years old) were enrolled in the study. The interdental biofilm of four interdental sites were collected. The real-time polymerase chain reaction (PCR) methodology were used to quantify (i) the following bacteria: Streptococcus spp., Streptococcus mutans, Lactobacillus spp., Enterococcus spp., and Enterococcus faecalis; (ii) the fungus Candida albicans; and (iii) total bacteria.
resultsStreptococcus spp. was the most abundant species, followed by Lactobacillus spp. and Enterococcus spp. Streptococcus spp. and Lactobacillus spp. were detected at all tested sites and Enterococcus spp. at 99% of sites. S. mutans was detected at only 28% of the tested sites and C. albicans was detected at 11% of sites. E. faecalis was never detected. In 54.5% of the biofilm inhabited by C. albicans, S. mutans was present. Moreover, 28% of the ID sites co-expressed S. mutans and Lactobacillus spp. The studied pathogens were organized into two correlated groups of species. Strikingly, the fungus C. albicans and the bacteria Enterococcus spp. cluster together, whereas Streptococcus spp., S. mutans and Lactobacillus spp. form one distinct cluster.
conclusionThe interdental biofilm of young caries-free adults is comprised of pathogens that are able to induce interproximal caries. That several of these pathogens are implicated in heart disease or other systemic diseases is an argument for the disruption of interdental biofilms using daily oral hygiene.
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