ArticlePloS one2017
Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis survival.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Epidemiology of Sarcoidosis in U.S. Veterans from 2003 to 2019.Annals of the American Thoracic Society · 2023Article
- A roadmap to ALS prevention: strategies and priorities.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Occupational lead exposure and survival with amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2023Article
- Pesticides applied to crops and amyotrophic lateral sclerosis risk in the U.S.Neurotoxicology · 2021Article
- Neuropathological profile of long-duration amyotrophic lateral sclerosis in military Veterans.Brain pathology (Zurich, Switzerland) · 2020Article
- Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis.NPJ genomic medicine · 2020Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundMilitary veterans may have higher rates of amyotrophic lateral sclerosis (ALS) mortality than non-veterans. Few studies, with sparse exposure information and mixed results, have studied relationships between military-related factors and ALS survival. We evaluated associations between military-related factors and ALS survival among U.S. military veteran cases.
methodsWe followed 616 medical record-confirmed cases from enrollment (2005-2010) in the Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis study until death or July 25, 2013, whichever came first. We ascertained vital status information from several sources within the Department of Veterans Affairs. We obtained information regarding military service, deployments, and 39 related exposures via standardized telephone interviews. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals. We adjusted for potential confounding and missing covariate data biases via inverse probability weights. We also used inverse probability weights to adjust for potential selection bias among a case group that included a disproportionate number of long-term survivors at enrollment.
resultsWe observed 446 deaths during 24,267 person-months of follow-up (median follow-up: 28 months). Survival was shorter for cases who served before 1950, were deployed to World War II, or mixed and applied burning agents, with HRs between 1.58 and 2.57. Longer survival was associated with exposure to: paint, solvents, or petrochemical substances; local food not provided by the Armed Forces; or burning agents or Agent Orange in the field with HRs between 0.56 and 0.73.
conclusionsAlthough most military-related factors were not associated with survival, associations we observed with shorter survival are potentially important because of the large number of military veterans.
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Registered trials
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