Evidence map›Paper›PMID 29016565›Full record

Trial reportThe American journal of gastroenterology2017

Colonoscopy vs. Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM): Rationale for Study Design.

Jason A Dominitz, Douglas J Robertson, Dennis J Ahnen, James E Allison, Margaret Antonelli, Kathy D Boardman, Maria Ciarleglio, Barbara J Del Curto, Grant D Huang, Thomas F Imperiale and 11 more

Registry-linked trialAbstract readComparative StudyPragmatic Clinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01239082 (CSP #577 - Colonoscopy vs. Fecal Immunochemical Testing in Reducing Mortality From Colorectal Cancer), which is not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01239082 naactive not recruitingnot on this map

CSP #577 - Colonoscopy vs. Fecal Immunochemical Testing in Reducing Mortality From Colorectal Cancer

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2012 to 2028Enrolled50,126ConditionsColorectal CancerArmsColonoscopy, FIT
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.

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  14. [What is confirmed in colorectal cancer screening?]Innere Medizin (Heidelberg, Germany) · 2025
    Review
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  16. Observational
  17. Optimal Approach to Colorectal Cancer Screening.Gastroenterology & hepatology · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 16 institutions in 1 country.

Jason A DominitzVA Puget Sound Health Care System and University of Washington School of Medicine, Seattle, Washington, USA.
Douglas J RobertsonVA Medical Center, White River Junction, Vermont and Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Dennis J AhnenVA Eastern Colorado Health Care System, Denver, Colorado, USA.
James E AllisonDivision of Gastroenterology, Department of Medicine, University of California San Francisco, Kaiser Division of Research, San Francisco, California, USA.
Margaret AntonelliCooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven, Connecticut, USA.
Kathy D BoardmanCooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, New Mexico, USA.
Maria CiarleglioDepartment of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
Barbara J Del CurtoCooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, New Mexico, USA.
Grant D HuangCooperative Studies Program Central Office, Office of Research and Development, Washington, DC, USA.
Thomas F ImperialeCenter for Innovation, Health Services Research and Development, Richard L. Roudebush VA Medical Center and Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Meaghan F LarsonVA Puget Sound Health Care System, Seattle, Washington, USA.
David LiebermanPortland VA Health Care System, Portland, Oregon, USA.
Theresa O'ConnorCooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven, Connecticut, USA.
Timothy J O'LearyOffice of Research and Development Veterans Health Administration Washington DC and Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Peter PeduzziDepartment of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
Dawn ProvenzaleVA Cooperative Studies Epidemiology Center-Durham and Duke University Medical Center, Durham, North Carolina, USA.
Aasma ShaukatCenter for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Healthcare System, Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA.
Shahnaz SultanCenter for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Healthcare System, Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA.
Amy VoorheesWhite River Junction VA Medical Center, White River Junction, Vermont, USA.
Robert WallaceCooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven, Connecticut, USA.
Peter D GuarinoCooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven, CT and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
VA Connecticut Healthcare System · USThe Coordinating Center · USWhite River Junction VA Medical Center · USYale University · USDurham VA Medical Center · USFred Hutch Cancer Center · USIndiana University School of MedicineMinneapolis VA Health Care System · USPortland VA Medical Center · USUniversity of California, San Francisco · USUniversity of Maryland, Baltimore · USUniversity of Minnesota · USUniversity of Washington · USVA Eastern Colorado Health Care System · USVA Office of Research and Development · USVA Puget Sound Health Care System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleColorectal cancer (CRC) is preventable through screening, with colonoscopy and fecal occult blood testing comprising the two most commonly used screening tests. Given the differences in complexity, risk, and cost, it is important to understand these tests' comparative effectiveness. STUDY

designThe CONFIRM Study is a large, pragmatic, multicenter, randomized, parallel group trial to compare screening with colonoscopy vs. the annual fecal immunochemical test (FIT) in 50,000 average risk individuals. CONFIRM examines whether screening colonoscopy will be superior to a FIT-based screening program in the prevention of CRC mortality measured over 10 years. Eligible individuals 50-75 years of age and due for CRC screening are recruited from 46 Veterans Affairs (VA) medical centers. Participants are randomized to either colonoscopy or annual FIT. Results of colonoscopy are managed as per usual care and study participants are assessed for complications. Participants testing FIT positive are referred for colonoscopy. Participants are surveyed annually to determine if they have undergone colonoscopy or been diagnosed with CRC. The primary endpoint is CRC mortality. The secondary endpoints are (1) CRC incidence (2) complications of screening colonoscopy, and (3) the association between colonoscopists' characteristics and neoplasia detection, complications and post-colonoscopy CRC. CONFIRM leverages several key characteristics of the VA's integrated healthcare system, including a shared medical record with national databases, electronic CRC screening reminders, and a robust national research infrastructure with experience in conducting large-scale clinical trials. When completed, CONFIRM will be the largest intervention trial conducted within the VA (ClinicalTrials.gov identifier: NCT01239082).

Indexed as

ColonoscopyImmunochemistryOccult BloodAgedCarcinomaColorectal NeoplasmsEarly Detection of CancerFecesFemaleHemoglobinsHumansMaleMiddle AgedUnited StatesUnited States Department of Veterans AffairsHemoglobins

Identifiers

PMID29016565
OpenAlexW2762467226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.