Evidence map›Paper›PMID 29016559›Full record

ArticleThe American journal of gastroenterology2018

The Reflux Improvement and Monitoring (TRIM) Program Is Associated With Symptom Improvement and Weight Reduction for Patients With Obesity and Gastroesophageal Reflux Disease.

Rena Yadlapati, John E Pandolfino, Olga Alexeeva, Dyanna L Gregory, Meredith R Craven, David Liebovitz, Abbey Lichten, Erin Seger, Moira Workman, Nora St Peter and 3 more

Open access · greenAbstract read
In one paragraph

Article in The American journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Guideline
  2. Overview of Pediatric Obesity as a Disease.Pediatric clinics of North America · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Rena YadlapatiUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
John E PandolfinoUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Olga AlexeevaUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Dyanna L GregoryUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Meredith R CravenUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
David LiebovitzUniversity of Chicago Pritzker School of Medicine, Chicago, Illinois, USA.
Abbey LichtenNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Erin SegerUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Moira WorkmanUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Nora St PeterNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Jenna CraftNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Bethany DoerflerNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Rajesh N KeswaniNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Northwestern University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Chicago · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Targeting Hypervigilance and Autonomic Arousal: the Psycho-physiologic Model of GERDR01DK092217 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JOHN E PANDOLFINO · 2012 to 2026
$5.0M
Training Grant in Gastrointestinal Physiology and PsychologyT32DK101363 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PANDOLFINO, JOHN E · 2014 to 2018
$1.2M
NCATS NIH HHS UL1 TR001422NIDDK NIH HHS R01 DK092217NIDDK NIH HHS T32 DK101363
6 · The paper itself

Abstract

objectivesCurrent healthcare systems do not effectively promote weight reduction in patients with obesity and gastroesophageal reflux disease (GERD). The Reflux Improvement and Monitoring (TRIM) program provides personalized, multidisciplinary, health education and monitoring over 6 months. In this study we aimed to (i) measure the effectiveness of TRIM on GERD symptoms, quality of life, and weight, and (ii) examine patient health beliefs related to TRIM.

methodsThis prospective mixed methods feasibility study was performed at a single center between September 2015 and February 2017, and included adult patients with GERD and a body mass index ≥30 kg/m

resultsAmong the +TRIM cohort (n=52), mean baseline GerdQ scores (8.7±2.9) decreased at 3 months (7.5±2.2; P<0.01) and 6 months (7.4±1.9; P=0.02). Mean GerdQ-DI scores decreased, but did not reach statistical significance. Compared with the -TRIM cohort (n=89), reduction in %EBW was significantly greater at 3, 6, and 12 months among the +TRIM cohort (n=52). In qualitative analysis, patients unanimously appreciated the multidisciplinary approach and utilized weight loss effectively to improve GERD symptoms.

conclusionsIn this mixed methods feasibility study, participation in TRIM was associated with symptom improvement, weight reduction, and patient engagement.

Indexed as

Attitude to HealthPatient Care PlanningPatient Education as TopicPatient ParticipationQuality of LifeWeight Reduction ProgramsAdultAgedFeasibility StudiesFemaleFocus GroupsGastroenterologistsGastroesophageal RefluxHealth EducatorsHumansMale

Identifiers

PMID29016559
PMCPMC5772963
OpenAlexW2762229961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.