Evidence map›Paper›PMID 29016556›Full record

ReviewPediatric research2018

The current status and future of cardiac stem/progenitor cell therapy for congenital heart defects from diabetic pregnancy.

Jianxiang Zhong, Shengbing Wang, Wei-Bin Shen, Sunjay Kaushal, Peixin Yang

Open access · bronzeAbstract readReview
In one paragraph

Review in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Pregestational Diabetes and Congenital Heart Defects.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jianxiang ZhongDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
Shengbing WangDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
Wei-Bin ShenDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
Sunjay KaushalDepartment of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland.
Peixin YangDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
University of Maryland, Baltimore · US

Funding

Mechanism of transplanted neonatal cardiac progenitor cells to repair ischemic myocardiumR01HL118491 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHUMACKER, PAUL T · 2014 to 2024
$4.4M
Apoptotic Mechanism of Maternal Diabetes-Induced Neural Tube DefectsR01DK083243 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI YANG, PEIXIN · 2010 to 2019
$3.1M
MicroRNA-Suppressed Mitochondrial Fusion in Mediating the Teratogenicity of Maternal Diabetes Leading to Heart DefectsR01HL134368 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, JIAN-YING, YANG, PEIXIN · 2017 to 2020
$2.4M
The Role of C-Kit Positive Cardiac Progenitors in Maternal Diabetes-Induced Heart Defects and the Therapeutic Values of These CellsR01HL139060 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI KAUSHAL, SUNJAY, YANG, PEIXIN · 2017 to 2020
$2.4M
Maternal Diabetes-Suppressed Vascular Signaling Induces Vasculopathy and Neural Tube DefectsR01HL131737 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI YANG, PEIXIN · 2016 to 2019
$2.1M
Molecular Signalling Pathways and Cellular Stress in Diabetic EmbryopathyR01DK103024 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI REECE, E. ALBERT, YANG, PEIXIN · 2014 to 2017
$1.7M
Autophagy and its Regulation in Diabetic EmbryopathyR01DK101972 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI YANG, PEIXIN · 2014 to 2017
$1.6M
NHLBI NIH HHS R01 HL118491NHLBI NIH HHS R01 HL131737NHLBI NIH HHS R01 HL134368NHLBI NIH HHS R01 HL139060NIDDK NIH HHS R01 DK083243NIDDK NIH HHS R01 DK101972NIDDK NIH HHS R01 DK103024
6 · The paper itself

Abstract

Pregestational maternal diabetes induces congenital heart defects (CHDs). Cardiac dysfunction after palliative surgical procedures contributes to the high mortality of CHD patients. Autologous or allogeneic stem cell therapies are effective for improving cardiac function in animal models and clinical trials. c-kit

Indexed as

Stem Cell TransplantationAnimalsCell DifferentiationCell LineageCells, CulturedDiabetes, GestationalEmbryonic Stem CellsFemaleHeart Defects, CongenitalHeart TransplantationHumansImmune SystemMiceMultipotent Stem CellsMyocytes, CardiacPregnancyProto-Oncogene Proteins c-kit

Identifiers

PMID29016556
PMCPMC5876137
OpenAlexW2763056242

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.