ArticlePsychosomatic medicine2018
Assessing Lifetime Stress Exposure Using the Stress and Adversity Inventory for Adults (Adult STRAIN): An Overview and Initial Validation.
Article in Psychosomatic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04082611 (The PREVENTION Trial), which is not on this map. Cited by 165 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The PREVENTION Trial: Precision Recommendations for Environmental Variables, Exercise, Nutrition and Training Interventions to Optimize Neurocognition
Who cites it
165 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Measuring adversity in the ABCD® Study: systematic review and recommendations for best practices.BMC medical research methodology · 2025Pooled it
- Relationships between childhood trauma and multiple sclerosis: A systematic review.Journal of psychosomatic research · 2022Pooled it
- Association between Stress at Work and Temporomandibular Disorders: A Systematic Review.BioMed research international · 2021Pooled it
- Effects of early- and mid-life stress on DNA methylation of genes associated with subclinical cardiovascular disease and cognitive impairment: a systematic review.BMC medical genetics · 2019Pooled it
- Nx4 Modulated Resting-State Functional Connectivity Between Amygdala and Prefrontal Cortex in a Placebo-Controlled, Crossover Trial.Brain connectivity · 2022Trial
- Alleviating Social Pain: A Double-Blind, Randomized, Placebo-Controlled Trial of Forgiveness and Acetaminophen.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Trial
- Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence.Journal of neural transmission (Vienna, Austria : 1996) · 2019Trial
- The Stress and Adversity Inventory for Adults (Adult STRAIN) in German: An overview and initial validation.PloS one · 2019Trial
- Neighborhood socioeconomic status and adolescent brain responses to peer feedback: Testing relationships with negative and positive affect assessed outside of the lab.Development and psychopathology · 2026Article
- From lifetime stressor exposure to daily stress experience: Associations with hair cortisol.Comprehensive psychoneuroendocrinology · 2026Article
- Validating the stress and adversity inventory for adults (Adult STRAIN) among urban middle-aged and older African Americans.Journal of health psychology · 2026Article
- Optimism, Lifetime Financial Stressors, and Mental Health Among Racially, Sexually, and Gender Minoritized Emerging Adults.Journal of racial and ethnic health disparities · 2026Article
- Lifetime stressor exposure, executive functioning, and internalizing symptoms during emerging adulthood.Scientific reports · 2026Article
- L-SOLCO Pilot Study: Examining Allostatic Load and Cancer Treatment Disparities.Journal of racial and ethnic health disparities · 2026Article
- Life experiences of humiliation, entrapment, and frontoparietal-cerebellar connectivity predict adolescent anxiety and depression symptoms.Psychological medicine · 2026Article
- A network analysis of lifetime stressor exposure, mental health, well-being, and immune cell mobilisation to acute stressors in young adults.Brain, behavior, & immunity - health · 2026Article
- Linking hair cortisol and life stress: The role of stress reactivity and habituation.Psychoneuroendocrinology · 2026Article
- Diagnosis of depression in adolescence signals improved inflammatory health in adulthood: Results from a nationally representative longitudinal study.Brain, behavior, and immunity · 2026Article
- Early life stress enhances the association between residential nature exposure and fasting blood glucose.PloS one · 2026Article
- Lifetime Stressor Exposure Profiles and Trait Risk for Substance Use in Young Adults.Substance use & misuse · 2026Article
105 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectiveNumerous theories have proposed that acute and chronic stressors may exert a cumulative effect on life-span health by causing biological "wear and tear," or allostatic load, which in turn promotes disease. Very few studies have directly tested such models, though, partly because of the challenges associated with efficiently assessing stress exposure over the entire life course. To address this issue, we developed the first online system for systematically assessing lifetime stress exposure, called the Stress and Adversity Inventory (STRAIN), and describe its initial validation here.
methodsAdults recruited from the community (n = 205) were administered the STRAIN, Childhood Trauma Questionnaire-Short Form, and Perceived Stress Scale, as well as measures of socioeconomic status, personality, social desirability, negative affect, mental and physical health complaints, sleep quality, computer-assessed executive function, and doctor-diagnosed general health problems and autoimmune disorders.
resultsThe STRAIN achieved high acceptability and was completed relatively quickly (mean = 18 minutes 39 seconds; interquartile range = 12-23 minutes). The structure of the lifetime stress data best fit two latent classes overall and five distinct trajectories over time. Concurrent associations with the Childhood Trauma Questionnaire-Short Form and Perceived Stress Scale were good (r values = .147-.552). Moreover, the STRAIN was not significantly related to personality traits or social desirability characteristics and, in adjusted analyses, emerged as the measure most strongly associated with all six of the health and cognitive outcomes assessed except current mental health complaints (β values = .16-.41; risk ratios = 1.02-1.04). Finally, test-retest reliability for the main stress exposure indices over 2-4 weeks was excellent (r values = .904-.919).
conclusionsThe STRAIN demonstrated good usability and acceptability; very good concurrent, discriminant, and predictive validity; and excellent test-retest reliability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.