Evidence map›Paper›PMID 29016550›Full record

ArticlePsychosomatic medicine2018

Assessing Lifetime Stress Exposure Using the Stress and Adversity Inventory for Adults (Adult STRAIN): An Overview and Initial Validation.

George M Slavich, Grant S Shields

Registry-linked trialAbstract read
In one paragraph

Article in Psychosomatic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04082611 (The PREVENTION Trial), which is not on this map. Cited by 165 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04082611 nacompletednot on this mapstarted 2019, after this paper: background citation

The PREVENTION Trial: Precision Recommendations for Environmental Variables, Exercise, Nutrition and Training Interventions to Optimize Neurocognition

TypeinterventionalSponsorSaint John's Cancer InstituteRan2019 to 2025Enrolled97ConditionsAlzheimer Disease, Mild Cognitive ImpairmentArmsData-Driven Clinical Recommendations, Coached Data-Driven Clinical Recommendations
3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Trial
  6. Alleviating Social Pain: A Double-Blind, Randomized, Placebo-Controlled Trial of Forgiveness and Acetaminophen.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019
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  14. L-SOLCO Pilot Study: Examining Allostatic Load and Cancer Treatment Disparities.Journal of racial and ethnic health disparities · 2026
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105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

George M SlavichFrom the Cousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California (Slavich); and the Department of Psychology, University of California, Davis, California (Shields).
Grant S Shields

Funding

Neural, Inflammatory, and Genomic Mechanisms Underlying Risk for Depression in AdolescenceK08MH103443 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SLAVICH, GEORGE MICHAEL · 2015 to 2018
$772k
NIMH NIH HHS K08 MH103443
6 · The paper itself

Abstract

objectiveNumerous theories have proposed that acute and chronic stressors may exert a cumulative effect on life-span health by causing biological "wear and tear," or allostatic load, which in turn promotes disease. Very few studies have directly tested such models, though, partly because of the challenges associated with efficiently assessing stress exposure over the entire life course. To address this issue, we developed the first online system for systematically assessing lifetime stress exposure, called the Stress and Adversity Inventory (STRAIN), and describe its initial validation here.

methodsAdults recruited from the community (n = 205) were administered the STRAIN, Childhood Trauma Questionnaire-Short Form, and Perceived Stress Scale, as well as measures of socioeconomic status, personality, social desirability, negative affect, mental and physical health complaints, sleep quality, computer-assessed executive function, and doctor-diagnosed general health problems and autoimmune disorders.

resultsThe STRAIN achieved high acceptability and was completed relatively quickly (mean = 18 minutes 39 seconds; interquartile range = 12-23 minutes). The structure of the lifetime stress data best fit two latent classes overall and five distinct trajectories over time. Concurrent associations with the Childhood Trauma Questionnaire-Short Form and Perceived Stress Scale were good (r values = .147-.552). Moreover, the STRAIN was not significantly related to personality traits or social desirability characteristics and, in adjusted analyses, emerged as the measure most strongly associated with all six of the health and cognitive outcomes assessed except current mental health complaints (β values = .16-.41; risk ratios = 1.02-1.04). Finally, test-retest reliability for the main stress exposure indices over 2-4 weeks was excellent (r values = .904-.919).

conclusionsThe STRAIN demonstrated good usability and acceptability; very good concurrent, discriminant, and predictive validity; and excellent test-retest reliability.

Indexed as

Adult Survivors of Child Adverse EventsAdultAgedFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesPsychometricsReproducibility of ResultsStress, PsychologicalYoung Adult

Identifiers

PMID29016550
PMCPMC5757659

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.