Evidence map›Paper›PMID 29016285›Full record

ArticleThe American journal of tropical medicine and hygiene2017

Development and Evaluation of a Loop-Mediated Isothermal Amplification Assay for the Detection of

Yongjian Xiao, Yafeng Xie, Man Xu, Shuangquan Liu, Chuanhao Jiang, Feijun Zhao, Tiebing Zeng, Zhuoran Liu, Jian Yu, Yimou Wu

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Laboratory Diagnostic Tools for Syphilis: Current Status and Future Prospects.Frontiers in cellular and infection microbiology · 2020
    Review
  10. Journal of clinical microbiology · 2019
    Article
  11. PCR detection for syphilis diagnosis: Status and prospects.Journal of clinical laboratory analysis · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yongjian XiaoInstitute of Pathogenic Biology Institute, Medical College, University of South China, Hengyang, China.
Yafeng XieHunan Province Cooperative Innovation Center for Molecular Targeted New Drug Study, Hengyang, China.
Man XuHunan Provincial Key Laboratory for Special Pathogen Prevention and Control, Hengyang, China.
Shuangquan LiuDepartment of Clinical Laboratory, The First Affiliated Hospital of University of South China, Hengyang, China.
Chuanhao JiangHunan Provincial Key Laboratory for Special Pathogen Prevention and Control, Hengyang, China.
Feijun ZhaoHunan Provincial Key Laboratory for Special Pathogen Prevention and Control, Hengyang, China.
Tiebing ZengHunan Provincial Key Laboratory for Special Pathogen Prevention and Control, Hengyang, China.
Zhuoran LiuDepartment of Clinical Laboratory, The Second Affiliated Hospital of University of South China, Hengyang, China.
Jian YuDepartment of Experimental Zoology, Medical College, University of South China, Hengyang, China.
Yimou WuHunan Provincial Key Laboratory for Special Pathogen Prevention and Control, Hengyang, China.
University of South China · CNFirst Affiliated Hospital of University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secondary syphilis (SS) has always been puzzling for the clinicians because of the similarity of the appearance of skin rashes with other dermatoses. Serological assays are useful, but less sensitive at an early stage of SS or when patients are immunodeficient. Therefore, there is an urgent need to develop a rapid and effective tool for the diagnosis of SS, which may play an important role in the control of epidemic syphilis outbreaks. In this study, we evaluated a loop-mediated isothermal amplification (LAMP) assay, targeting gene encoding the basic membrane protein of

Indexed as

Treponema pallidumAdolescentAdultDNA, BacterialFemaleHumansMaleMiddle AgedNucleic Acid Amplification TechniquesSensitivity and SpecificitySpecimen HandlingSyphilisYoung AdultDNA, Bacterial

Identifiers

PMID29016285
PMCPMC5805031
OpenAlexW2763429801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.