Evidence map›Paper›PMID 28994822›Full record

ArticleScientific data2017

Whole genome DNA methylation sequencing of the chicken retina, cornea and brain.

Isac Lee, Bejan A Rasoul, Ashton S Holub, Alannah Lejeune, Raymond A Enke, Winston Timp

Abstract readDataset
In one paragraph

Article in Scientific data, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. DNA methylation in poultry: a review.Journal of animal science and biotechnology · 2023
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Temporal and Isoform-Specific Expression ofFrontiers in molecular neuroscience · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isac LeeDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Bejan A RasoulDepartment of Biology, James Madison University, Harrisonburg, VA 22807, USA.
Ashton S HolubDepartment of Biology, James Madison University, Harrisonburg, VA 22807, USA.
Alannah LejeuneDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Raymond A EnkeDepartment of Biology, James Madison University, Harrisonburg, VA 22807, USA.
Winston TimpDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0003-2083-6027

Funding

T32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer ResearchT32CA153952 · NCI · JOHNS HOPKINS UNIVERSITY · PI Denis Wirtz · 2015 to 2026
$3.5M
T-32 NIH Postdoctoral Training Program in Nanotechnology for Cancer Medicine NTCMT32CA130840 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2008 to 2012
$1.2M
NCI NIH HHS T32 CA130840NCI NIH HHS T32 CA153952
6 · The paper itself

Abstract

Whole genome bisulfite sequencing (WGBS) analysis of DNA methylation uses massively parallel next generation sequencing technology to characterize global epigenetic patterns and fluctuations throughout a range of tissue samples. Development of the vertebrate retina is thought to involve extensive epigenetic reprogramming during embryogenesis. The chicken embryo (Gallus gallus) is a classic model system for studying developmental biology and retinogenesis, however, there are currently no publicly available data sets describing the developing chicken retinal methylome. Here we used Illumina WGBS analysis to characterize genome-wide patterns of DNA methylation in the developing chicken retina as well as cornea and brain in an effort to further our understanding of retina-specific epigenetic regulation. These data will be valuable to the vision research community for correlating global changes in DNA methylation to differential gene expression between ocular and neural tissues during critical developmental time points of retinogenesis in the chicken retina.

Indexed as

BrainChickensCorneaDNA MethylationRetinaAnimalsGenomeWhole Genome Sequencing

Identifiers

PMID28994822
PMCPMC5634322

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.