Evidence map›Paper›PMID 28994651›Full record

ArticleeLife2017

Marisa Connell, Helen Chen, Jihong Jiang, Chia-Wei Kuan, Abbas Fotovati, Tony Lh Chu, Zhengcheng He, Tess C Lengyell, Huaibiao Li, Torsten Kroll and 10 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 68 citations in OpenAlex.

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  7. Hyaluronan-mediated motility receptor-mediated aerobic glycolysis enhances stem-like properties and chemoresistance in lung adenocarcinoma.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 3 countries.

Marisa Connell *Department of Paediatrics, University of British Columbia, Vancouver, Canada.ORCID http://orcid.org/0000-0002-7594-2137
Helen Chen *Department of Paediatrics, University of British Columbia, Vancouver, Canada.
Jihong JiangDepartment of Paediatrics, University of British Columbia, Vancouver, Canada.
Chia-Wei KuanDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
Abbas FotovatiDepartment of Paediatrics, University of British Columbia, Vancouver, Canada.
Tony Lh ChuDepartment of Paediatrics, University of British Columbia, Vancouver, Canada.
Zhengcheng HeDepartment of Paediatrics, University of British Columbia, Vancouver, Canada.
Tess C LengyellCentre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.
Huaibiao LiLeibniz Institute on Aging-Fritz Lipmann Institute, Beutenbergstrasse, Germany.ORCID http://orcid.org/0000-0003-4086-3321
Torsten KrollLeibniz Institute on Aging-Fritz Lipmann Institute, Beutenbergstrasse, Germany.
Amanda M LiDepartment of Paediatrics, University of British Columbia, Vancouver, Canada.
Daniel GoldowitzCentre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.
Lucien FrappartLeibniz Institute on Aging-Fritz Lipmann Institute, Beutenbergstrasse, Germany.
Aspasia PloubidouLeibniz Institute on Aging-Fritz Lipmann Institute, Beutenbergstrasse, Germany.
Millan S PatelDepartment of Medical Genetics, University of British Columbia, Vancouver, Canada.
Linda M PilarskiCross Cancer Institute, Department of Oncology, University of Alberta, Edmonton, Canada.
Elizabeth M SimpsonCentre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.
Philipp F LangeDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
Douglas W AllanDepartment of Cellular and Physiological Sciences, Life Sciences Centre, University of British Columbia, Vancouver, Canada.
Christopher A MaxwellDepartment of Paediatrics, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-0860-4031
University of British Columbia · CALeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DEUniversity of Alberta · CA

Funding

UCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2M
CIHR OBC 134036CIHR OBC 134038NIH HHS U42 OD012210
6 · The paper itself

Abstract

Oriented cell division is one mechanism progenitor cells use during development and to maintain tissue homeostasis. Common to most cell types is the asymmetric establishment and regulation of cortical NuMA-dynein complexes that position the mitotic spindle. Here, we discover that HMMR acts at centrosomes in a PLK1-dependent pathway that locates active Ran and modulates the cortical localization of NuMA-dynein complexes to correct mispositioned spindles. This pathway was discovered through the creation and analysis of

Indexed as

Cell ProliferationAnimalsBrainCell Cycle ProteinsDyneinsExtracellular Matrix ProteinsHyaluronan ReceptorsMice, KnockoutNeural Stem CellsNuclear ProteinsPolo-Like Kinase 1Protein Serine-Threonine KinasesProto-Oncogene Proteinsran GTP-Binding ProteinSpindle ApparatusCell Cycle ProteinsDyneinsExtracellular Matrix Proteinshyaluronan-mediated motility receptorHyaluronan ReceptorsNuclear ProteinsNuma1 protein, mousePolo-Like Kinase 1Protein Serine-Threonine KinasesProto-Oncogene Proteinsran GTP-Binding ProteinRan protein, mouseasymmetric cell divisioncell biologydevelopmental biologyhumanmouseneurogenesisspindle orientationstem cells

Identifiers

PMID28994651
PMCPMC5681225
OpenAlexW2761280186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.