ArticleMagnetic resonance in medicine2018
Scan-rescan of axcaliber, macromolecular tissue volume, and g-ratio in the spinal cord.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status.Brain : a journal of neurology · 2023Review
- The Value of Various Post-Processing Modalities of Diffusion Weighted Imaging in the Detection of Multiple Sclerosis.Brain sciences · 2023Review
- Mapping the human connectome using diffusion MRI at 300 mT/m gradient strength: Methodological advances and scientific impact.NeuroImage · 2022Review
- Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions.NeuroImage. Clinical · 2022Review
- Scan-rescan repeatability of axonal imaging metrics using high-gradient diffusion MRI and statistical implications for study design.NeuroImage · 2021Article
- Generic acquisition protocol for quantitative MRI of the spinal cord.Nature protocols · 2021Article
- Validating pore size estimates in a complex microfiber environment on a human MRI system.Magnetic resonance in medicine · 2021Article
- Towards in vivo g-ratio mapping using MRI: Unifying myelin and diffusion imaging.Journal of neuroscience methods · 2021Review
- HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy.Scientific reports · 2020Article
- Diffusion MRI microstructural models in the cervical spinal cord - Application, normative values, and correlations with histological analysis.NeuroImage · 2019Article
- Magnetic resonance imaging correlates of neuro-axonal pathology in the MS spinal cord.Brain pathology (Zurich, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeRecent MRI techniques have been introduced that can extract microstructural information in the white matter, such as the density or macromolecular content. Translating quantitative MRI to the clinic raises many challenges in terms of acquisition strategy, modeling of the MRI signal, artifact corrections, and metric extraction (template registration and partial volume effects). In this work, we investigated the scan-rescan repeatability of several quantitative MRI techniques in the human spinal cord.
methodsAxCaliber metrics, macromolecular tissue volume, and the fiber g-ratio were estimated in the spinal cord of eight healthy subjects, scanned and rescanned the same day in two different sessions.
resultsScan-rescan repeatability deviation was 3% for all metrics, in average in the white matter of all subjects. Intraclass correlation coefficient was up to 0.9. A three-way analysis of variance showed significant effects of white matter pathway, laterality, and subject.
conclusionThe present study suggests that quantitative MRI gives stable measurements of white matter microstructure in the spinal cord of healthy subjects. Our findings remain to be evaluated in diseased populations. Magn Reson Med 79:2759-2765, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.