Evidence map›Paper›PMID 28994305›Full record

ArticleEpigenomics2018

Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia.

Zheng Ge, Yan Gu, Qi Han, Justin Sloane, Qinyu Ge, Goufeng Gao, Jinlong Ma, Huihui Song, Jiaojiao Hu, Baoan Chen and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. IKAROS in Acute Leukemia: A Positive Influencer or a Mean Hater?International journal of molecular sciences · 2023
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Zheng GeDepartment of Hematology, Zhongda Hospital, Medical School of Southeast University, Southeast University Institute of Hematology, Nanjing 210009, China.
Yan GuDepartment of Hematology, Zhongda Hospital, Medical School of Southeast University, Southeast University Institute of Hematology, Nanjing 210009, China.
Qi HanDepartment of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.
Justin SloaneDepartment of Obstetrics & Gynecology, Abington Jefferson-Health, Abington, PA 19001, USA.
Qinyu GeState Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China.
Goufeng GaoDepartment of Pathology & Laboratory Medicine, University of California-Davis Medical Center, Sacramento, CA 95817, USA.
Jinlong MaDepartment of Hematology, Zhongda Hospital, Medical School of Southeast University, Southeast University Institute of Hematology, Nanjing 210009, China.
Huihui SongDepartment of Hematology, Zhongda Hospital, Medical School of Southeast University, Southeast University Institute of Hematology, Nanjing 210009, China.
Jiaojiao HuDepartment of Hematology, Zhongda Hospital, Medical School of Southeast University, Southeast University Institute of Hematology, Nanjing 210009, China.
Baoan ChenDepartment of Hematology, Zhongda Hospital, Medical School of Southeast University, Southeast University Institute of Hematology, Nanjing 210009, China.
Sinisa DovatInternational Cooperative Leukemia Group & International Cooperative Laboratory of Hematology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
Chunhua SongInternational Cooperative Leukemia Group & International Cooperative Laboratory of Hematology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
Zhongda Hospital Southeast University · CNNanjing Medical University · CNPenn State Milton S. Hershey Medical Center · USSoutheast University · CNState Key Laboratory of Digital Medical EngineeringThomas Jefferson University Hospital · USUniversity of California Davis Medical Center · US

Funding

Targeting CRLF2 and Ikaros Alterations to Reduce Health Disparities in Childhood LeukemiaR01CA209829 · NCI · LOMA LINDA UNIVERSITY · PI DOVAT, SINISA, DUERKSEN-HUGHES, PENELOPE J · 2016 to 2020
$2.0M
Targeting CK2 oncogenic pathway to overcome drug resistance in high-risk leukemiaR01CA213912 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI DOVAT, SINISA · 2017 to 2021
$1.8M
NCI NIH HHS R01 CA209829NCI NIH HHS R01 CA213912
6 · The paper itself

Abstract

aimClinical significance of plant homeodomain finger 2 (PHF2) expressions is explored in acute lymphoblastic leukemia (ALL) patients.

methodsmRNA level was examined by qPCR. The retroviral gene expression, shRNA knockdown and chromatin-immunoprecipitation are used to observe IKAROS regulation on PHF2 transcription.

resultsPHF2 expression is significantly reduced in subsets of ALL patients, and PHF2

conclusionOur results demonstrate that the IKAROS promotes PHF2 expression, and suggest that PHF2

Indexed as

AdolescentAdultAgedBone MarrowCell LineCell ProliferationChildFemaleHomeodomain ProteinsHumansIkaros Transcription FactorMaleMiddle AgedPrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosisRNA, MessengerHomeodomain ProteinsIkaros Transcription FactorIKZF1 protein, humanPHF2 protein, humanRNA, MessengerRNA, Small Interferingacute lymphoblastic leukemiahistone modificationIKZF1PHF2

Identifiers

PMID28994305
PMCPMC5992565
OpenAlexW2760845237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.