Evidence map›Paper›PMID 28994023›Full record

ArticleMolecular and cellular biochemistry2018

Treatment with pentylenetetrazole (PTZ) and 4-aminopyridine (4-AP) differently affects survival, locomotor activity, and biochemical markers in Drosophila melanogaster.

Deividi C S Soares, José L R Portela, Daniel H Roos, Nathane R Rodrigues, Karen K Gomes, Giulianna E Macedo, Thais Posser, Jeferson L Franco, Waseem Hassan, Robson L Puntel

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Deividi C S SoaresPrograma de Pós-Graduação em Bioquímica, Universidade Federal do Pampa, Campus Uruguaiana, BR 472 km 585, Caixa Postal 118, Uruguaiana, RS, 97508-000, Brazil.
José L R PortelaPrograma de Pós-Graduação em Bioquímica, Universidade Federal do Pampa, Campus Uruguaiana, BR 472 km 585, Caixa Postal 118, Uruguaiana, RS, 97508-000, Brazil.
Daniel H RoosPrograma de Pós-Graduação em Bioquímica, Universidade Federal do Pampa, Campus Uruguaiana, BR 472 km 585, Caixa Postal 118, Uruguaiana, RS, 97508-000, Brazil.
Nathane R RodriguesPrograma de Pós-Graduação em Ciências Biológicas, Interdisciplinary Center for Biotechnology Research, Universidade Federal do Pampa, Campus São Gabriel, Avenida Antônio Trilha 1847, Centro, São Gabriel, RS, 97300-000, Brazil.
Karen K GomesPrograma de Pós-Graduação em Ciências Biológicas, Interdisciplinary Center for Biotechnology Research, Universidade Federal do Pampa, Campus São Gabriel, Avenida Antônio Trilha 1847, Centro, São Gabriel, RS, 97300-000, Brazil.
Giulianna E MacedoPrograma de Pós-Graduação em Ciências Biológicas, Interdisciplinary Center for Biotechnology Research, Universidade Federal do Pampa, Campus São Gabriel, Avenida Antônio Trilha 1847, Centro, São Gabriel, RS, 97300-000, Brazil.
Thais PosserPrograma de Pós-Graduação em Ciências Biológicas, Interdisciplinary Center for Biotechnology Research, Universidade Federal do Pampa, Campus São Gabriel, Avenida Antônio Trilha 1847, Centro, São Gabriel, RS, 97300-000, Brazil.
Jeferson L FrancoPrograma de Pós-Graduação em Ciências Biológicas, Interdisciplinary Center for Biotechnology Research, Universidade Federal do Pampa, Campus São Gabriel, Avenida Antônio Trilha 1847, Centro, São Gabriel, RS, 97300-000, Brazil.
Waseem HassanInstitute of Chemical Sciences, University of Peshawar, Peshawar, Khyber Pakhtunkhwa, 25120, Pakistan.
Robson L PuntelPrograma de Pós-Graduação em Bioquímica, Universidade Federal do Pampa, Campus Uruguaiana, BR 472 km 585, Caixa Postal 118, Uruguaiana, RS, 97508-000, Brazil. robson_puntel@yahoo.com.br.
Universidade Federal do Pampa · BRUniversity of Peshawar · PK

Funding

CNPq/FAPERGS/DECIT/SCTIEMS/ PRONEM (#11/2029-1)Conselho Nacional de Desenvolvimento Científico e Tecnológico (# 449428/2014-1)Conselho Nacional de Desenvolvimento Científico e Tecnológico (# 456207/2014-7)
6 · The paper itself

Abstract

PTZ is a convulsive agent that acts via selective blockage of GABA

Indexed as

4-AminopyridineAnimalsDrosophila melanogasterLocomotionPentylenetetrazole4-AminopyridinePentylenetetrazoleEnzyme activityEpileptogenic drugsGene expressionOxidative stress

Identifiers

PMID28994023
OpenAlexW2761174127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.