ArticlePlanta2018
Tobacco alpha-expansin EXPA4 plays a role in Nicotiana benthamiana defence against Tobacco mosaic virus.
Article in Planta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Functional Analysis ofPlants (Basel, Switzerland) · 2026Article
- Selected cell wall-associated components in plant defense responses against microbial pathogens.Frontiers in plant science · 2026Review
- Identification of EXPA4 as a key gene in cotton salt stress adaptation through transcriptomic and coexpression network analysis of root tip protoplasts.BMC plant biology · 2025Article
- The role of rhamnolipids in the growth and defense responses of passion fruit plants.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Strigolactones Negatively Regulate Tobacco Mosaic Virus Resistance inInternational journal of molecular sciences · 2024Article
- Alpha-expansins: more than three decades of wall creep and loosening in fruits.Plant molecular biology · 2024Review
- Applications of Virus-Induced Gene Silencing in Cotton.Plants (Basel, Switzerland) · 2024Review
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- Plant drought tolerance provided through genome editing of the trehalase gene.Plant signaling & behavior · 2021Article
- Plant Cell Wall as a Key Player During Resistant and Susceptible Plant-Virus Interactions.Frontiers in microbiology · 2021Review
- Transcriptome analysis of yellow passion fruit in response to cucumber mosaic virus infection.PloS one · 2021Article
- The Expression of Potato Expansin A3 (Viruses · 2020Article
- Expression of Two α-Type Expansins fromInternational journal of molecular sciences · 2019Article
- The chaperone-like protein CDC48 regulates ascorbate peroxidase in tobacco.Journal of experimental botany · 2019Article
- Over-expression of GmKR3, a TIR-NBS-LRR type R gene, confers resistance to multiple viruses in soybean.Plant molecular biology · 2019Article
- Massive up-regulation of LBD transcription factors and EXPANSINs highlights the regulatory programs of rhizomania disease.Molecular plant pathology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
MAIN
conclusionTobacco EXPA4 plays a role in Nicotiana benthamiana defence against virus attack and affects antioxidative metabolism and phytohormone-mediated immunity responses in tobacco. Expansins are cell wall-loosening proteins known for their endogenous functions in cell wall extensibility during plant growth. The effects of expansins on plant growth, developmental processes and environment stress responses have been well studied. However, the exploration of expansins in plant virus resistance is rarely reported. In the present study, virus-induced gene silencing (VIGS) and Agrobacterium-mediated transient overexpression were conducted to investigate the role of Nicotiana tabacum alpha-expansin 4 (EXPA4) in modulating Tobacco mosaic virus (TMV-GFP) resistance in Nicotiana benthamiana. The results indicated that silencing of EXPA4 reduced the sensitivity of N. benthamiana to TMV-GFP, and EXPA4 overexpression accelerated virus reproduction on tobacco. In addition, our data suggested that the changes of virus accumulation in response to EXPA4 expression levels could further affect the antioxidative metabolism and phytohormone-related pathways in tobacco induced by virus inoculation. EXPA4-silenced plants with TMV-GFP have enhanced antioxidant enzymes activities, which were down-regulated in virus-inoculated 35S:EXPA4 plants. Salicylic acid accumulation and SA-mediated defence genes induced by TMV-GFP were up-regulated in EXPA4-silenced plants, but depressed in 35S:EXPA4 plants. Furthermore, a VIGS approach was used in combination with exogenous phytohormone treatments, suggesting that EXPA4 has different responses to different phytohormones. Taken together, these results suggested that EXPA4 plays a role in tobacco defence against viral pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.