ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Vigilance, the Amygdala, and Anxiety in Youths with a History of Institutional Care.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.JAMA network open · 2023Pooled it
- Dimensions of Early-Life Adversity and Attention Biases in Childhood and Adolescence: A Systematic Review.Clinical child and family psychology review · 2026Review
- Corticotropin releasing hormone-expressing inputs to the thalamic paraventricular nucleus: pathways from mother to memory?Neurobiology of stress · 2026Article
- Volatility-driven learning in human infants.Science advances · 2025Article
- The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research.Molecular psychiatry · 2024Review
- Specifying the timescale of early life unpredictability helps explain the development of internalising and externalising behaviours.Scientific reports · 2024Article
- Sensory processing challenges as a novel link between early caregiving experiences and mental health.Development and psychopathology · 2023Article
- Genetic Tagging Uncovers a Robust, Selective Activation of the Thalamic Paraventricular Nucleus by Adverse Experiences Early in Life.Biological psychiatry global open science · 2023Article
- Sows' Responses to Piglets in Distress: An Experimental Investigation in a Natural Setting.Animals : an open access journal from MDPI · 2023Article
- An exploratory study of resting-state functional connectivity of amygdala subregions in posttraumatic stress disorder following trauma in adulthood.Scientific reports · 2022Article
- Children's value-based decision making.Scientific reports · 2022Article
- A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- EEG revealed improved vigilance regulation after stress exposure under Nx4 - A randomized, placebo-controlled, double-blind, cross-over trial.IBRO neuroscience reports · 2021Article
- The Pubertal Stress Recalibration Hypothesis: Potential Neural and Behavioral Consequences.Child development perspectives · 2021Article
- What was learned from studying the effects of early institutional deprivation.Pharmacology, biochemistry, and behavior · 2021Review
- Inflammatory modulation of the associations between prenatal maternal depression and neonatal brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Early life stress and development: potential mechanisms for adverse outcomes.Journal of neurodevelopmental disorders · 2020Review
- Anxious to see you: Neuroendocrine mechanisms of social vigilance and anxiety during adolescence.The European journal of neuroscience · 2020Article
- Childhood Adversity and Neural Development: A Systematic Review.Annual review of developmental psychology · 2019Article
- Pubertal stress recalibration reverses the effects of early life stress in postinstitutionalized children.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEarly adversity is commonly associated with alterations of amygdala circuitry and increased anxiety. While many theoretical and clinical accounts of early adversity suggest that it increases vigilance to threatening stimuli, the present study tested whether heightened anxiety and amygdala reactivity associated with early adversity enhanced goal-directed attention for threatening stimuli. Showing this association would provide support that these adversity-induced alterations are developmental adaptations of the individual.
methods34 children and adolescents who experienced early adversity in the form of previous institutionalization (PI) (26 female, mean age=13.49 years) and a comparison group of 33 children and adolescents who were reared by their biological parents since birth (16 female, mean age=13.40 years) underwent fMRI scanning while completing a visual search task that involved quickly locating a negative (fearful face) or positive target (happy face) in an array of neutral distractor stimuli (neutral faces).
resultsAcross both groups, individual differences in vigilant behavior were positively associated with amygdala responses for negative versus positive stimuli. However, a moderation analysis revealed that the degree to which amygdala responses were greater for negative versus positive stimuli was associated with greater anxiety symptomology for PI youth, but not comparison youth.
conclusionsTogether, these findings suggest that institutional care strengthens linkages between amygdala reactivity and anxiety, perhaps serving to enhance goal-directed attention. The findings are discussed as both adaptations as well as risk to the individual.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.