Evidence map›Paper›PMID 28993781›Full record

ArticleFrontiers in immunology2017

Natural Killer T Cell-Targeted Immunotherapy Mediating Long-term Memory Responses and Strong Antitumor Activity.

Nyambayar Dashtsoodol, Tomokuni Shigeura, Takuya Tashiro, Minako Aihara, Toshihiro Chikanishi, Hiromi Okada, Keigo Hanada, Hirokazu Sano, Akihiko Kurogi, Masaru Taniguchi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Epigenetic control ofFrontiers in immunology · 2023
    Article
  5. Article
  6. Article
  7. Allogeneic CAR Invariant Natural Killer T Cells Exert Potent Antitumor Effects through Host CD8 T-Cell Cross-Priming.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  8. Review
  9. Article
  10. Article
  11. Natural killer T cell activation increases iNOSJournal for immunotherapy of cancer · 2019
    Article
  12. Review
  13. Article
  14. Advances in NKT cell Immunotherapy for Glioblastoma.Journal of cancer science & therapy · 2018
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Nyambayar DashtsoodolLaboratory for Immune Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Tomokuni ShigeuraLaboratory for Immune Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Takuya TashiroFaculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
Minako AiharaLaboratory for Immune Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Toshihiro ChikanishiLaboratory for Immune Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Hiromi OkadaLaboratory for Immune Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Keigo HanadaLaboratory for Immune Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Hirokazu SanoLaboratory for Immune Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Akihiko KurogiLaboratory for Immune Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Masaru TaniguchiLaboratory for Immune Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
RIKEN Center for Integrative Medical Sciences · JPNiigata University of Pharmacy and Applied Life Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current tumor therapies, including immunotherapies, focus on passive eradication or at least reduction of the tumor mass. However, cancer patients quite often suffer from tumor relapse or metastasis after such treatments. To overcome these problems, we have developed a natural killer T (NKT) cell-targeted immunotherapy focusing on active engagement of the patient's immune system, but not directly targeting the tumor cells themselves. NKT cells express an invariant antigen receptor α chain encoded by

Indexed as

adjuvant activityCD1dimmunotherapylong-term memory responsesnatural killer T cellneoglycolipidtumor immunology

Identifiers

PMID28993781
PMCPMC5622408
OpenAlexW2758079131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.