Evidence map›Paper›PMID 28993778›Full record

ArticleFrontiers in immunology2017

Potential Role of Vδ2

Nupur Bhatnagar, Pierre-Marie Girard, Moises Lopez-Gonzalez, Céline Didier, Lio Collias, Corinne Jung, Diane Bollens, Claudine Duvivier, Cassandre Von Platen, Daniel Scott-Algara and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
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  12. Review
  13. Article
  14. What Can Gamma Delta T Cells Contribute to an HIV Cure?Frontiers in cellular and infection microbiology · 2020
    Review
  15. Review
  16. Article
  17. Review
  18. Regulatory functions of γδ T cells.Cellular and molecular life sciences : CMLS · 2018
    Review
  19. Protective Role ofJournal of immunology research · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Nupur BhatnagarInstitut Pasteur, Unité Cytokines et Inflammation, Paris, France.
Pierre-Marie GirardAP-HP, Hôpital Saint-Antoine, Paris, France.
Moises Lopez-GonzalezInstitut Pasteur, Unité Cytokines et Inflammation, Paris, France.
Céline DidierInstitut Pasteur, Unité Cytokines et Inflammation, Paris, France.
Lio ColliasAP-HP, Hôpital Européen Georges Pompidou, Paris, France.
Corinne JungAP-HP, Hôpital Européen Georges Pompidou, Paris, France.
Diane BollensAP-HP, Hôpital Saint-Antoine, Paris, France.
Claudine DuvivierCentre Médical de l'Institut Pasteur, Centre d'Infectiologie Necker Pasteur, Paris, France.
Cassandre Von PlatenInstitut Pasteur, Center for Translational Science, Paris, France.
Daniel Scott-AlgaraInstitut Pasteur, Unité Cytokines et Inflammation, Paris, France.
Laurence WeissInstitut Pasteur, Unité Cytokines et Inflammation, Paris, France.
ANRS EP-56 Group
Institut Pasteur · FRSorbonne Université · FRUniversité Paris Cité · FRHôpital Européen · FRHôpital Européen Georges-Pompidou · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although conventional regulatory T cells (Tregs) are sufficient in controlling low residual T-cell activation in ART-treated patients, they are not efficient in controlling exaggerated immune activation associated with high levels of HIV replication in primary HIV infection (PHI). Our previous data suggested that double negative (DN) T cells including mainly γδ DN T cells play a role in the control of immune activation in PHI. Since γδ T cells are capable of exerting regulatory functions, we investigated their implication as Tregs in PHI as well as chronic HIV infection (CHI). In a cross-sectional study of 58 HIV-infected patients, in the primary and the chronic phase either ART-treated or untreated (UT), we analyzed phenotype and cytokine production of γδ T cells using flow cytometry. Cytokine production was assessed following

Indexed as

chronic HIV infectionimmune activationprimary HIV infectionTGF-βVδ2+ γδ T cells

Identifiers

PMID28993778
PMCPMC5622291
OpenAlexW2791655586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.