ArticleFrontiers in neurology2017
Histological Characteristics of Intracranial Atherosclerosis in a Chinese Population: A Postmortem Study.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Imaging endpoints of intracranial atherosclerosis using vessel wall MR imaging: a systematic review.Neuroradiology · 2021Pooled it
- Colchicine in patients with acute ischaemic stroke or transient ischaemic attack (CHANCE-3): multicentre, double blind, randomised, placebo controlled trial.BMJ (Clinical research ed.) · 2024Trial
- Differentiated risk factors for stroke recurrence in anterior versus posterior circulation intracranial atherosclerosis: A high-resolution vessel wall imaging study.Neuroimage. Reports · 2026Article
- Follow-up Optical Coherence Tomography Evaluation of Endothelialization in Drug-eluting Stents for Symptomatic Vertebral Artery Stenosis: a Report of Nine Cases.Clinical neuroradiology · 2026Article
- Exploring the Association Between Heart Rate Variability and Intracranial Atherosclerosis in Middle-Aged or over Community-Dwelling Adults.Diagnostics (Basel, Switzerland) · 2025Article
- Association of Intracranial Plaque Features with the Severity of White Matter Hyperintensities in Middle-Aged and Older Community-Dwelling Adults.Biomedicines · 2025Article
- The burden of intracranial atherosclerosis on cerebral small vessel disease: A community cohort study.Annals of clinical and translational neurology · 2025Article
- Colchicine for preventing stroke in patients with and without intracranial atherosclerotic stenosis: a prespecified analysis of a randomized clinical trial.EClinicalMedicine · 2025Article
- Endovascular Treatment of Symptomatic Basilar Artery Stenosis.Neurointervention · 2023Article
- Characteristics of intracranial plaque in patients with non-cardioembolic stroke and intracranial large vessel occlusion.Stroke and vascular neurology · 2023Article
- Vessel Wall Imaging of Intracranial Arteries: Fundamentals and Clinical Applications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023Review
- Association between vascular calcification in intracranial vertebrobasilar circulation and luminal stenosis.Neuroradiology · 2022Article
- Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis.Neuroradiology · 2022Article
- Stroke incidence and cognitive outcomes of intracranial atherosclerotic stenosis: study protocol for a multicenter, prospective, observational cohort study.Annals of translational medicine · 2022Article
- Intracranial Arterial Calcification and Intracranial Atherosclerosis: Close but Different.Frontiers in neurology · 2022Article
- Vessel wall MR imaging of aortic arch, cervical carotid and intracranial arteries in patients with embolic stroke of undetermined source: A narrative review.Frontiers in neurology · 2022Review
- Clopidogrel treatment inhibits P2YEuropean journal of pharmacology · 2021Article
- Role of Blood Lipid Levels and Lipid-Lowering Therapy in Stroke Patients with Different Levels of Cerebral Artery Diseases: Reconsidering Recent Stroke Guidelines.Journal of stroke · 2021Review
- Understanding the Clinical Implications of Intracranial Arterial Calcification Using Brain CT and Vessel Wall Imaging.Frontiers in neurology · 2021Article
- Vessel wall MR imaging of intracranial atherosclerosis.Cardiovascular diagnosis and therapy · 2020Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundAnterior and posterior circulation atherosclerosis differ in vascular risk factors and stroke mechanisms. However, few studies have compared the pathological features between these lesions. Using a series of intracranial artery specimens, we characterized the intracranial atherosclerotic lesions and compared pathological features among different arteries of the intracranial vasculature.
methodsIntracranial large arteries of 32 consecutively recruited autopsy cases of Chinese adults aged 45 years or older were examined pathologically using routine histology and immunostaining, to characterize the pathological features of the atherosclerotic lesions. We analyzed middle cerebral arteries (MCAs) (both left and right), vertebral arteries (VAs) (side more affected), and basilar arteries (BAs).
resultsProgressive atherosclerotic lesions were present in 91(71%) of the 128 arteries examined. Features of complicated plaques were infrequently detected: plaque hemorrhage was encountered in 12%, neovasculature in 12%, lumen thrombi in 13%, macrophage infiltration in 20%, and calcification in 25% of arteries. Luminal narrowing of MCA was the most severe, followed by VA; the BA least stenotic (37 ± 25 vs. 30 ± 24 vs. 20 ± 20%, all
conclusionIntracranial atherosclerotic plaques were commonly present in this sample, but the lesions generally lacked features of complicated plaques. MCA lesions had demonstrable differences compared with VA and BA lesions. Further studies are needed to determine whether these characteristics indicate a distinctive atherosclerotic phenotype for the intracranial vasculature.
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