ArticleFrontiers in psychiatry2017
Executive Control and Striatal Resting-State Network Interact with Risk Factors to Influence Treatment Outcomes in Alcohol-Use Disorder.
Article in Frontiers in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relating Functional Connectivity and Alcohol Use Disorder: A Systematic Review and Derivation of Relevance Maps for Regions and Connections.Human brain mapping · 2025Pooled it
- Repetitive deep TMS in alcohol dependent patients halts progression of white matter changes in early abstinence.Psychiatry and clinical neurosciences · 2024Trial
- The effects of nalmefene on the impulsive and reflective system in alcohol use disorder: A resting-state fMRI study.Psychopharmacology · 2022Trial
- Sex differences in tobacco smokers: Executive control network and frontostriatal connectivity.Drug and alcohol dependence · 2019Trial
- A preliminary randomized clinical trial of naltrexone reduces striatal resting state functional connectivity in people with methamphetamine use disorder.Drug and alcohol dependence · 2018Trial
- Temporal Interference Electrical Stimulation for Neuropsychiatric Disorders: Mechanisms, Applications, and Translational Perspectives.International journal of molecular sciences · 2026Review
- Context-dependent asymmetries in intertemporal decision-making: a comparative study of substance use disorder and control groups.Substance abuse treatment, prevention, and policy · 2026Article
- Altered Structural Connectivity and Functional Brain Dynamics in Individuals With Heavy Alcohol Use Elucidated via Network Control Theory.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Altered Physiological, Affective, and Functional Connectivity Responses to Acute Stress in Patients With Alcohol Use Disorder.Biological psychiatry global open science · 2024Article
- Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Compensation patterns and altered functional connectivity in alcohol use disorder with and without Korsakoff's syndrome.Brain communications · 2024Article
- Craving dynamics and related cerebral substrates predict timing of use in alcohol, tobacco, and cannabis use disorders.Addiction neuroscience · 2023Article
- Resting state connectivity in people living with HIV before and after stopping heavy drinking.Frontiers in psychiatry · 2023Article
- Resting-state connectivity subtype of comorbid PTSD and alcohol use disorder moderates improvement from integrated prolonged exposure therapy in Veterans.Psychological medicine · 2023Article
- The Moderating Role of Sex in the Relation between Cue-Induced Craving and Resting-State Functional Connectivity in the Salience Network of Non-Clinically Diagnosed Drinkers.European addiction research · 2023Article
- Value-based decision-making network functional connectivity correlates with substance use and delay discounting behaviour among young adults.NeuroImage. Clinical · 2023Article
- Deep brain stimulation of the nucleus accumbens in the treatment of severe alcohol use disorder: a phase I pilot trial.Molecular psychiatry · 2022Article
- Brain Network Allostasis after Chronic Alcohol Drinking Is Characterized by Functional Dedifferentiation and Narrowing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Neuroimaging in alcohol use disorder: From mouse to man.Journal of neuroscience research · 2022Review
- Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder.Alcoholism, clinical and experimental research · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Alterations within mesocorticolimbic terminal regions commonly occur with alcohol use disorder (AUD). As pathological drug-seeking behavior may arise as a consequence of alcohol-induced neuroadaptations, it is critical to understand how such changes increase the likelihood of relapse. This report examined resting-state functional connectivity (RSFC) using both a seed-based and model-free approach in individuals in treatment for AUD and how dysregulation of network connectivity contributes to treatment outcomes. In order to provide a mechanism by which neural networks promote relapse, interactive effects of mesocorticolimbic connectivity and AUD risk factors in treatment completers and non-completers were examined. AUD group showed stronger RSFC between striatum, insula, and anterior cingulate cortex than controls. Within the AUD group, non-completers compared to completers showed enhanced RSFC between (1) striatum-insula, (2) executive control network (ECN)-amygdala, and (3) basal ganglia/salience network and striatum, precuneus, and insula. Completers showed enhanced RSFC between striatum-right dorsolateral prefrontal cortex. Furthermore, completers and non-completers differed in relationships between RSFC and relapse risk factors, where non-completers exhibited positive associations between craving intensity and RSFC of striatum-insula and ECN-amygdala. These findings provide evidence for interactions between corticolimbic connectivity in AUD and craving and establish an important link between network connectivity and dynamic risk factors that contribute to relapse. Results demonstrate that relapse vulnerability is attributed to craving dysregulation manifested by enhanced connectivity in striato-limbic regions and diminished corticostriatal connectivity.
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