Evidence map›Paper›PMID 28993722›Full record

ArticleFrontiers in neuroscience2017

Type 1 Diabetes and Impaired Awareness of Hypoglycemia Are Associated with Reduced Brain Gray Matter Volumes.

Petr Bednarik, Amir A Moheet, Heidi Grohn, Anjali F Kumar, Lynn E Eberly, Elizabeth R Seaquist, Silvia Mangia

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Thalamic Nuclei Atrophy in Type 1 Diabetes Mellitus Across Disease Duration.Journal of magnetic resonance imaging : JMRI · 2026
    Article
  2. The cognitive consequences of hypoglycemia in diabetes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Petr BednarikDepartment of Radiology, Center for Magnetic Resonance Research, University of MinnesotaMinneapolis, MN, United States.
Amir A MoheetDepartment of Medicine, University of MinnesotaMinneapolis, MN, United States.
Heidi GrohnDepartment of Radiology, Center for Magnetic Resonance Research, University of MinnesotaMinneapolis, MN, United States.
Anjali F KumarDepartment of Medicine, University of MinnesotaMinneapolis, MN, United States.
Lynn E EberlyDivision of Biostatistics, University of MinnesotaMinneapolis, MN, United States.
Elizabeth R SeaquistDepartment of Medicine, University of MinnesotaMinneapolis, MN, United States.
Silvia MangiaDepartment of Radiology, Center for Magnetic Resonance Research, University of MinnesotaMinneapolis, MN, United States.
University of Minnesota · USResonance Research (United States) · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)KL2TR000113 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$5.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 DiabetesR01DK099137 · NIDDK · UNIVERSITY OF MINNESOTA · PI MANGIA, SILVIA · 2014 to 2018
$2.5M
Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 DiabetesR56DK099137 · NIDDK · UNIVERSITY OF MINNESOTA · PI MANGIA, SILVIA · 2013 to 2013
$248k
NCATS NIH HHS KL2 TR000113NCATS NIH HHS UL1 TR000114NIBIB NIH HHS P41 EB015894NIDDK NIH HHS R01 DK099137NIDDK NIH HHS R56 DK099137NINDS NIH HHS P30 NS076408
6 · The paper itself

Abstract

In this study, we retrospectively analyzed the anatomical MRI data acquired from 52 subjects with type 1 diabetes (26M/26F, 36 ± 11 years old, A1C = 7.2 ± 0.9%) and 50 age, sex and BMI frequency-matched non-diabetic controls (25M/25F, 36 ± 14 years old). The T1D group was further sub-divided based on whether subjects had normal, impaired, or indeterminate awareness of hypoglycemia (

Indexed as

brain volumeshypoglycemiahypoglycemia unawarenessstructural MRItype 1 diabetes

Identifiers

PMID28993722
PMCPMC5622182
OpenAlexW2759217676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.