Evidence map›Paper›PMID 28993713›Full record

ArticleJournal of fluorine chemistry2017

Synthesis of pH indicators for Cerenkov imaging by electrophilic substitution of bromine by fluorine in an aromatic system.

Alexander V Kachur, Alejandro D Arroyo, Nikaela W Bryan, Sarah J Saylor, Anatoliy V Popov, E James Delikatny

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fluorine chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexander V KachurDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alejandro D ArroyoDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nikaela W BryanDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sarah J SaylorDepartment of Chemistry and Biochemistry, Misher College of Arts and Sciences, University of the Sciences, Philadelphia, PA 19104.
Anatoliy V PopovDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
E James DelikatnyDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
University of Pennsylvania · USUniversity of the Sciences · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8M
Cerenkov Specific Contrast AgentsR01EB018645 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI DELIKATNY, EDWARD J · 2014 to 2017
$1.4M
Cerenkov imaging for in vivo pH determination of the tumor microenvironmentF31CA206453 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ARROYO PACHECO, ALEJANDRO D. · 2016 to 2018
$106k
NCI NIH HHS F31 CA206453NCI NIH HHS P30 CA016520NIBIB NIH HHS R01 EB018645NIGMS NIH HHS T32 GM008076
6 · The paper itself

Abstract

Direct electrophilic fluorination using molecular fluorine gas is used in organic synthesis to create novel fluorine-containing compounds with potential beneficial activity that could not be obtained by nucleophilic substitution. In this paper, we report a novel electrophilic substitution of bromine by fluorine in an aromatic system. The mechanism of this type of fluorination was explored using the reaction between bromothymolsulfonphthalein (Bromothymol Blue) and dilute fluorine gas under acidic conditions. Substitution occurs in the bromine atoms located in the

Indexed as

bromineBromothymol blueCerenkov imagingelectrophilic fluorinationfluorinepH indicatorsThymol Blue

Identifiers

PMID28993713
PMCPMC5630228
OpenAlexW2733387360

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.