ArticleNature communications2017
A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Pooled it
- Menstrual cycle modulates the effect of BDNF Val66Met variant on category learning.Biology of sex differences · 2026Article
- Synaptic mechanisms for differential severity of social preference deficits in male and female mice induced by diminished activity-dependent BDNF.Frontiers in neuroscience · 2026Article
- Deficiency of the palmitoyl acyltransferase ZDHHC7 modulates depression-like behaviour in female mice after a mild chronic stress paradigm.Translational psychiatry · 2025Article
- Enriched housing differentially alters allostatic load and cardiopulmonary responses to wildfire-related smoke in male and female mice.Journal of toxicology and environmental health. Part A · 2024Article
- Practical solutions for including sex as a biological variable (SABV) in preclinical neuropsychopharmacological research.Journal of neuroscience methods · 2024Review
- Epigenetic mechanisms underlying sex differences in the brain and behavior.Trends in neurosciences · 2024Review
- Transcriptional Profiling of Rat Prefrontal Cortex after Acute Inescapable Footshock Stress.Genes · 2023Article
- Recent Studies on the Development of Nicotine Abuse and Behavioral Changes Induced by Chronic Stress Depending on Gender.Brain sciences · 2023Review
- Diminished activity-dependent BDNF signaling differentially causes autism-like behavioral deficits in male and female mice.Frontiers in psychiatry · 2023Article
- Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum ofFrontiers in molecular neuroscience · 2023Article
- Social interaction following prepubertal stress alters prefrontal gene expression associated with cell signalling and oligodendrocytes.Translational psychiatry · 2022Article
- An allostatic epigenetic memory on chromatin footprints after double-hit acute stress.Neurobiology of stress · 2022Article
- Sex hormone fluctuation and increased female risk for depression and anxiety disorders: From clinical evidence to molecular mechanisms.Frontiers in neuroendocrinology · 2022Review
- Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy.Neurobiology of stress · 2022Article
- FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats.The journal of headache and pain · 2022Article
- Genomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene.Translational psychiatry · 2022Article
- Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory.Translational psychiatry · 2022Article
- Mean Girls: Social Stress Models for Female Rodents.Current topics in behavioral neurosciences · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Males and females use distinct brain circuits to cope with similar challenges. Using RNA sequencing of ribosome-bound mRNA from hippocampal CA3 neurons, we found remarkable sex differences and discovered that female mice displayed greater gene expression activation after acute stress than males. Stress-sensitive BDNF Val66Met mice of both sexes show a pre-stressed translational phenotype in which the same genes that are activated without applied stress are also induced in wild-type mice by an acute stressor. Behaviourally, only heterozygous BDNF Val66Met females exhibit spatial memory impairment, regardless of acute stress. Interestingly, this effect is not observed in ovariectomized heterozygous BDNF Val66Met females, suggesting that circulating ovarian hormones induce cognitive impairment in Met carriers. Cognitive deficits are not observed in males of either genotype. Thus, in a brain region not normally associated with sex differences, this work sheds light on ways that genes, environment and sex interact to affect the transcriptome's response to a stressor.Animals' response to acute stress is known to be influenced by sex and genetics. Here the authors performed RNA-seq on actively translated mRNAs in hippocampal CA3 neurons in mice, and document the effects of sex and genotype (i.e., BDNF Val66Met) on acute stress-induced gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.